Multi-window CT based Radiomic signatures in differentiating indolent versus aggressive lung cancers in the National Lung Screening Trial: a retrospective study

Table 1 Demographic characteristic of patients

Variable	Aggressive cancer (n = 77)	Indolent cancer (n = 20)	Mixed cancer (n = 17)	P
Age				0.196
Mean ± SD	65.29 ± 5.45	62.60 ± 4.71	65.18 ± 5.17
Pack years smoked				0.704
Mean ± SD	65.01 ± 25.83	62.40 ± 18.77	51.43 ± 16.96
Sex				0.006
Female	24 (31.17)	14(70.00)	9 (52.94)
Male	53 (68.83)	6(30.00)	8 (47.06)
Family history of lung cancer				0.386
Yes	20 (25.97)	6(30.00)	2 (11.76)
No	57 (74.03)	14(70.00)	15 (88.24)
Smoke status				0.309
Current	41 (53.25)	14(70.00)	8 (47.06)
Former	36 (46.75)	6(30.00)	9 (52.94)
History of COPD				0.035
Yes	16 (20.78)	0 (0)	1 (5.88)
No	61 (79.22)	20 (100)	16 (94.12)

Note: Data are presented as n, or n (%) Abbreviation: COPD chronic obstructive pulmonary disease
For the 77 patients with aggressive lung cancer, 16 of them have scans at 3 time points (baseline, the first follow up, the second follow up);For the 20 patients with indolent lung cancer, 2 of them have scans at 3 time points (baseline, the first follow up, the second follow up);For the 17 patients with mixed lung cancer, the nodules of 12 of them have indolent pattern at first but aggressive since the second scan, while the nodules of the rest 5 patients have aggressive pattern at first but indolent since the second scan

ISSN: 1470-7330