Table 1 Characteristics of NET patients with myocardial lesions on 68Ga-DOTATATE PET at the time point of their initial NET diagnosis
Study population (n = 15) | CCC NET registrya (n = 629) | P value | |
|---|---|---|---|
Age (yrs) | 65 (± 9) | 63 (± 14) | 0.915 |
Male sex | 9/15 (60%) | 333/616 (54%) | 0.795 |
Location of primary tumor | |||
Jejunum/Ileum | 11/15 (73%) | 182/387 (47%) | N/A |
Appendix | 1/15 (6.7%) | 18/387 (4.6%) | |
Colon | 2/15 (13%) | 27/387 (7.0%) | |
Undetermined | 1/15 (6.7%) | 15/387 (3.9%) | |
Tumor grading | |||
G1 | 5/10 (50%) | 126/255 (49%) | 0.353 |
G2 | 3/10 (30%) | 109/255 (43%) | |
G3 | 2/10 (20%) | 20/255 (8%) | |
Ki67-Index | |||
≤ 2% | 5/12 (42%) | 131/292 (45%) | 0.049b |
> 2–20% | 4/12 (33%) | 142/292 (49%) | |
> 20% | 3/12 (25%) | 19/292 (7%) | |
Disease stage | |||
Localized | 2/15 (13%) | 44/227 (19%) | 0.743 |
Regional metastasis | 11/15 (73%) | N/A N/A | |
Regional metastasis only | 2/15 (13%) | 21/162 (13%) | 1.000 |
Distant metastasis | 11/15 (73%) | 113/162 (70%) | 1.000 |
Hepatic | 6/11 (55%) | N/A N/A | |
Peritoneal | 4/11 (36%) | N/A N/A | |
Osseous | 6/11 (55%) | N/A N/A | |
Myocardial | 5/11 (45%) | N/A N/A | |
Other | 2/11 (18%) | N/A N/A | |
Chromogranin A (ng/mL) | 175 (95–9578) | N/A N/A | |
Elevated Chromogranin A | 7/10 (70%) | 178/312 (57%) | 0.526 |
5-HIAA urine secretion (mg/24 h) | 26 (10–80) | N/A N/A | |
Elevated 5-HIAA urine secretion | 4/6 (66%) | 178/312 (57%) | 0.701 |
Carcinoid heart disease | 0/15 (0%) | N/A N/A | |