Additional value of 18F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer

Table 3 C-indices (95% confidence interval) for the prediction of pathologic complete response by metabolic response in TN and HER2-positive breast cancer

	Pathologic complete response
	Breast	Axilla	Total
TN: ΔSUVmax PET1-PET3
Breast	0.85 (0.72 – 0.98)	0.83 (0.69 – 0.98)	0.82 (0.66 – 0.98)
Axilla	0.82 (0.68 – 0.95)	0.82 (0.68 – 0.97)	0.83 (0.67 – 0.98)
Breast + axilla	0.86 (0.74 – 0.98)	0.86 (0.72 – 0.99)	0.85 (0.69 – 1.00)
p-value^*	0.78	0.60	0.63
HER2-positive: SUVmax PET2
Breast	0.62 (0.44 – 0.81)	0.65 (0.47 – 0.84)	0.64 (0.47 – 0.81)
Axilla	0.68 (0.52 – 0.84)	0.77 (0.62 – 0.92)	0.67 (0.51 - 0.83)
Breast + axilla	0.72 (0.56 – 0.89)	0.78 (0.63 – 0.92)	0.72 (0.57 – 0.88)
p-value^*	0.11	0.06	0.06

^* p-value for the improvement in c-index by the addition of metabolic response in the axilla

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