Skip to main content

Table 1 Baseline and treatment characteristics according to subtype

From: Additional value of 18F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer

 

TN

HER2+

All

(n = 45)

(n = 60)

(n = 105)

n

(%)

n

(%)

n

(%)

Age (years)

 Median (IQR)

50

(36–55)

45

(37–52)

47

(37–54)

Tumour size on MRI (mm)

 Median (IQR)

31

(22–45)

38

(22–60)

33

(22–50)

Disease stage

 II

19

(42%)

26

(43%)

45

(43%)

 III

26

(58%)

34

(57%)

60

(57%)

Baseline axillary staging method

 Positive, pre-SNPa

1

(2%)

0

(0%)

1

(1%)

 Positive, FNA

44

(98%)

60

(100%)

104

(99%)

Grade

 1–2

13

(29%)

25

(42%)

38

(36%)

 3

16

(36%)

14

(23%)

30

(29%)

 Unknown

16

(36%)

21

(35%)

37

(35%)

Histology

 Ductal

43

(96%)

55

(92%)

98

(93%)

 Lobular

0

(0%)

4

(7%)

4

(4%)

 Other

2

(4%)

1

(2%)

3

(3%)

HR-status

 ER- and PR-

45

(100%)

29

(48%)

74

(71%)

 ER+ and/or PR+

0

(0%)

31

(52%)

31

(30%)

Treatment

 ACb

45

(100%)

0

(0%)

45

(43%)

 PTCc

0

(0%)

60

(100%)

60

(57%)

PET assessment

 PET1 performed

45

(100%)

60

(100%)

105

(100%)

 PET2 performed

35

(78%)

45

(75%)

80

(76%)

 PET3 performed

38

(84%)

47

(78%)

84

(80%)

  1. TN triple-negative, HER2+ HER2-positive, n number of patients, PA pathology, SNP sentinel node procedure, FNA fine needle aspiration, ER oestrogen receptor, PR progesterone receptor, AC doxorubicin/cyclophosphamide, PTC paclitaxel/trastuzumab/carboplatin
  2. aSNP performed before PET1, but remaining positive axillary lymph node in situ outside surgical region
  3. bNineteen patients switched treatment after PET3: six to capecitabine/docetaxel, ten to high-dose carboplatin/thiotepa/cyclophosphamide, three to paclitaxel (+/- carboplatin)
  4. cTwo patients received paclitaxel/trastuzumab/carboplatin plus pertuzumab, and one patients switched to 5-fluorouracil/epirubicin/cyclophosphamide plus trastuzumab after PET3