Table 1 Risk factors predisposing to infection with different organisms
From: Chest CT for suspected pulmonary complications of oncologic therapies: how I review and report
Involved cell line | Granulocytes, Monocytes | B-Lymphocytes | T-Lymphocytes |
|---|---|---|---|
Immune defect | Unspecific cellular defense | Antibody-deficiency | Specific cellular defense |
Disease | Solid tumours myeloid leukaemia short term (<5 d) neutropenia | B-cell-lymphoma, B-ALL, lymphotoxic therapy (steroids) | T-cell-lymphoma, T-ALL, lymphotoxic therapy continuous immunosuppression, allogenic stem cell transplant, organ transplant, T-cell-specific drugs (Alemzutumab, Antithymocyte globulin) |
Organisms | Bacteria (gram+, gram-) in neutropenia > 10 d also fungi (lung: Aspergillus, liver/spleen: Candida, pleura/paranasal sinus: Mucormyces) | Bacteria (gram +, gram-) | Pneumocystis jirovecii (PCP), viruses, fungi (Toxoplasma, Listeria, Coccidiomyces) |
Pneumocystis jirovecii (PCP) |