Skip to main content

Table 1 Risk factors predisposing to infection with different organisms

From: Chest CT for suspected pulmonary complications of oncologic therapies: how I review and report

Involved cell line Granulocytes, Monocytes B-Lymphocytes T-Lymphocytes
Immune defect Unspecific cellular defense Antibody-deficiency Specific cellular defense
Disease Solid tumours myeloid leukaemia short term (<5 d) neutropenia B-cell-lymphoma, B-ALL, lymphotoxic therapy (steroids) T-cell-lymphoma, T-ALL, lymphotoxic therapy continuous immunosuppression, allogenic stem cell transplant, organ transplant, T-cell-specific drugs (Alemzutumab, Antithymocyte globulin)
Organisms Bacteria (gram+, gram-) in neutropenia > 10 d also fungi (lung: Aspergillus, liver/spleen: Candida, pleura/paranasal sinus: Mucormyces) Bacteria (gram +, gram-) Pneumocystis jirovecii (PCP), viruses, fungi (Toxoplasma, Listeria, Coccidiomyces)
Pneumocystis jirovecii (PCP)
  1. Adapted from: Diederich S and Giagounidis A (2014) Therapy-associated changes of the lung and pleura in cancer patients. RadiologieUp2date 14: 331-346