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Table 2 Summary of the results of test accuracy in studies comparing whole-body MRI with FDG-PET/CT in the detection of sites of skeletal metastases

From: Evidence-based medicine and clinical fluorodeoxyglucose PET/MRI in oncology

Study

Population & setting

Reference standard

Outcome [95 % CI]

PET-CT

WB-MRI

Sensitivity

PPV

Sensitivity

PPV

Pfannenberg et al. (2007) [15]

Recurrent melanoma

Histology or 8 months follow-up

91 [78–97] %

91 % [78–97] %

100 [90–100] %

90 % [76–96] %

Self-controlled study (n = 64)

Schmidt et al. (2007) [16]

Non-CNS tumours and suspicion of bone metastases

≥6 months imaging follow-up

77 [68–84] %

94 [67–97] %

94 [88–97] %

94 [88–97] %

Self-controlled study (n = 35)

Schmidt et al. (2009) [17]

Recurrent Colorectal Cancer

Follow-up (mean 11 months)

50 [15–85] %

100 [51–100] %

100 [51–100] %

100 [51–100] %

Self-controlled study (n = 24)

Laurent et al. (2010) [19]

Recurrent melanoma

Histology or 6 months follow-up

71 [45–88] %

100 [72–100] %

93 [69–99] %

100 [77–100] %

Self-controlled study (n = 35)

Jouvet et al. (2014) [20]

Recurrent melanoma

Histology or ≥6 months follow-up

88 [64–97] %

93 [70–99] %

100 [81–100] %

76 [55–89] %

Self-controlled study (n = 37)

Weighted averages

(n = 195)

 

80 [74–85] %

94 [89–97] %

96 [92–98] %

92 [87–95] %