Fig. 3
From: Primary hepatic neuroendocrine tumors: comparing CT and MRI features with pathology
MRI and histology of grade 3 PHNET. Transverse T1-weighted (a), transverse T2-weighted (b), contrast-enhanced dynamic T1-weighted at the arterial phase (c) and delayed phase (d). Figure e and f illustrate liver arterial reconstruction, and transverse diffusion-weighted imaging(b = 800 s/mm2, respectively). This grade 3 tumor (8.4 cm in size) was located in the right lobe with a cystic change in the liver wall. Multiple satellite nodules show marked peripheral enhancement in the arterial phase and slight hyper-intensity relative to the surrounding liver parenchyma in the delayed phase. Diffusion-weighted imaging (Figure f) shows high peripheral signal intensity, which reflects the diffuse restriction of water. Figure e confirms that the tumor blood supply comes from the liver artery. HE staining of liver tumor cells with atypia, varying sizes, multiple mitosis rates, and irregular nucleoli (g). Staining for the neuroendocrine marker, synaptophysin (Syn) was positive (h). Magnifications: G and H = 100X