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Table 5 Intraprostatic FDG uptake as a predictor of pathological Gleason sum

From: FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy

 

Pathological Gleason sum

Spearman r

P -value

 

≤7

≥8

  
 

No. (%)

No. (%)

  

Clinical reporting

IPFU-

22 (84.6)

4 (15.4)

 

0.003

IPFU+

4 (30.8)

9 (69.2)

  

Blinded reading

IPFU- (Score 0 or 1)

17 (85.0)

3 (15.0)

 

0.013

IPFU+ (Score 2 to 4)

9 (47.4)

10 (52.6)

  

Score vs. post-RP Gleason pattern

  

0.58

0.0001

Score vs. post-RP Gleason sum

  

0.50

0.001

Score vs. pathological T stage

  

0.32

0.040

Quantitative analysis

IPFU- (SUVmax < 4.0)

20 (83.3)

4 (16.7)

 

0.010

IPFU+ (SUVmax ≥ 4.0)

6 (42.9)

8 (57.1)

  

SUVmax vs. post-RP Gleason pattern

  

0.46

0.004

SUVmax vs. post-RP Gleason sum

  

0.44

0.006

SUVmax vs. pathological T stage

  

0.35

0.030

  1. FDG = 18F-fluorodeoxyglucose; IPFU = intraprostatic FDG uptake; IPFU- = IPFU-negative; IPFU + = IPFU-positive; RP = radical prostatectomy; SUVmax = maximum standardized uptake value.