Figure 3

Fused FDG-PET/CT transaxial slices in a patient with a Gleason sum 9 (4 + 5) PCa at biopsy showing (A) a highly hypermetabolic prostatic focus (positive clinical report; score = 3; SUV _max   = 7.1) and (C) one of two bone metastases, which were intensely hypermetabolic and lytic on CT (E). Three months after ADT initiation, there was a complete metabolic response of the primary PCa lesion (B). The bone lesions underwent at least a partial metabolic response (D) and became sclerotic on CT (F). Possibly, the osteoblasts repair activity contributed to the residual FDG uptake. The metabolic response was consistent with the biochemical response, with the PSA decreasing from 125 to 1.5 ng/L.