Whole-body diffusion-weighted MRI for staging of women with cancer during pregnancy: a pilot study
© Dresen et al. 2015
Published: 2 October 2015
To evaluate whole-body diffusion weighted magnetic resonance imaging (WB-DWI) for staging of women with cancer during pregnancy.
Twenty patients diagnosed with cancer during pregnancy underwent WB-DWI additional to conventional imaging in this prospective single centre study. Reproducibility of WB-DWI between 2 readers was evaluated using Cohen’s κ statistics and accuracy was compared to conventional imaging for assessing primary tumour site, nodal metastases and visceral metastases. Histopathology after surgery or biopsy was the primary reference standard.
Ten patients had breast cancer, 3 lymphoma, 2 cervical uterine cancer, 1 ovarian borderline tumour, 2 colon cancer, 1 lung cancer and 1 a conjunctival tumour. The WB-DWI readers showed very good agreement for lesion detection, κ = 0.94. With WB-DWI, reader 1 detected 38 of 41 malignant lesions, reader 2 thirty-nine lesions and conventional imaging 27. WB-DWI showed sensitivity of 95% (95% CI: 74-99) for both readers and specificity up to 99% (95% CI: 76-99) compared to 50% sensitivity (95% CI: 28-72) with 100% (95% CI: 97-100) specificity for conventional imaging. For staging distant metastases, WB-DWI sensitivities were 66.7% (95% CI: 13-98) and 100% (95% CI: 40-100) respectively for reader 1 and 2 with specificities of 94.1% (95% CI: 69-99) and 100% (95% CI: 40-100) compared to sensitivity of 33.3% (95% CI: 1.7-87) and specificity of 100% (95% CI: 77-100) for conventional imaging.
WB-DWI is feasible for single-step non-invasive imaging based cancer staging during pregnancy showing additional value to conventional imaging procedures for detecting distant and nodal metastases.
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