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FDG-PET/CT pitfalls in gynecological and genitourinary oncological imaging
Cancer Imaging volume 15, Article number: P42 (2015)
Learning objectives
1. To understand the role of FDG PET/CT imaging in the multimodality investigation of gynecological and genitourinary cancers.
2. To describe the mechanism of action and technical pitfalls of FDG-PET/CT.
3. To highlight key imaging features of physiological and non-physiological FDG uptake and show how this is essential for interpretation of gynecological and genitourinary FDG-PET/CT studies.
4. to review the pathophysiological mechanisms leading to potentially false-positive and false-negative assessments.
Content organisation
Introduction of FDG-PET/CT
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° Mechanism of action
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° Role in gynecological and genitourinary oncological imaging
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° FDG-PET/CT imaging protocols
False positives in gynecological and genitourinary oncological imaging:
∘ Physiological FDG-PET uptake – pictorial examples of uptake in endometrium and ovaries
∘ Non-physiological FDG-PET uptake – pictorial examples of pelvic inflammatory disease, fibroids, endometriosis
False negatives in gynecological and genitourinary oncological imaging:
∘ Physiological FDG-PET uptake – pictorial examples of urinary excretion masking malignant lesions
∘ No/low FDG uptake – pictorial examples of necrotic lymphadenopathy and low grade tumours
∘ Artefacts
Pearls explaining how to minimise false interpretation
Conclusion
FDG-PET/CT has a useful role in gynecological and genitourinary oncological imaging. However, understanding of physiological and non-physiological FDG- PET uptake is vital to understand potential false positive and false negatives in interpretation.
FDG PET/CT should be used as one part of the multimodality investigation of gynecological and genitourinary cancers.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Lakhani, A., Khan, S., Bharwani, N. et al. FDG-PET/CT pitfalls in gynecological and genitourinary oncological imaging. Cancer Imaging 15 (Suppl 1), P42 (2015). https://doi.org/10.1186/1470-7330-15-S1-P42
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DOI: https://doi.org/10.1186/1470-7330-15-S1-P42