Volume 15 Supplement 1
FDG-PET/CT pitfalls in gynecological and genitourinary oncological imaging
© Lakhani et al. 2015
Published: 2 October 2015
1. To understand the role of FDG PET/CT imaging in the multimodality investigation of gynecological and genitourinary cancers.
2. To describe the mechanism of action and technical pitfalls of FDG-PET/CT.
3. To highlight key imaging features of physiological and non-physiological FDG uptake and show how this is essential for interpretation of gynecological and genitourinary FDG-PET/CT studies.
4. to review the pathophysiological mechanisms leading to potentially false-positive and false-negative assessments.
° Mechanism of action
° Role in gynecological and genitourinary oncological imaging
° FDG-PET/CT imaging protocols
False positives in gynecological and genitourinary oncological imaging:
∘ Physiological FDG-PET uptake – pictorial examples of uptake in endometrium and ovaries
∘ Non-physiological FDG-PET uptake – pictorial examples of pelvic inflammatory disease, fibroids, endometriosis
False negatives in gynecological and genitourinary oncological imaging:
∘ Physiological FDG-PET uptake – pictorial examples of urinary excretion masking malignant lesions
∘ No/low FDG uptake – pictorial examples of necrotic lymphadenopathy and low grade tumours
Pearls explaining how to minimise false interpretation
FDG-PET/CT has a useful role in gynecological and genitourinary oncological imaging. However, understanding of physiological and non-physiological FDG- PET uptake is vital to understand potential false positive and false negatives in interpretation.
FDG PET/CT should be used as one part of the multimodality investigation of gynecological and genitourinary cancers.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.