Volume 15 Supplement 1
Are contouring time and multimodality imaging prognostic factors for radiation therapy of advanced head and neck cancer?
© Eller et al. 2015
Published: 2 October 2015
To evaluate if contouring time and multimodality imaging are prognostic factors for radiation therapy of advanced head and neck cancer (HNC) 207 patients were analyzed retrospectively between 2001-2012.
Material and methods
Before 2007 radiation treatment planning-CT was done without contrast enhancement, MRI and 18F-FDG-PET/CT were used only occasionally. From 2007 contrast enhanced planning-CT in addition to multimodality imaging was used routinely for every HNC. Additionally, in unclear or equivocal imaging findings of lymph nodes a re-report was performed with a higher sensitivity at the expense of specificity to minimise geographical miss in the contouring procedure for radiation treatment and to maximise the binary decisions for each lymph node (malignant vs. benign). The re-reports were done in conjunction with radio oncologists, nuclear physicians and radiologists. The mean contouring time was 60min before 2007, 150min after 2007 (including the time for a re-report). Clinical outcome was assessed in two groups (group I: 2001-2007, n=113 vs. group II: 2008-2012, n=94).
Regional control was significantly higher in group II (log-rank-test p=0.03): group I after 3 years 76%, group II after 3 years 88%. Locoregional control for 207 patients shows no difference in survival (p=0.08); however, inclusion of 340 patients would lead to a p-value p<0.05.
Imaging findings of multimodality imaging and a critical re-report of these imaging findings in conjunction with a longer contouring time may have an impact on clinical outcome. However, this overtime is not reimbursed. A close collaboration of radiooncologists, nuclear physicians and radiologists in the radiation treatment planning process may have a benefit for patients with advanced HNC.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.