Volume 14 Supplement 1

Proceedings of the International Cancer Imaging Society (ICIS) 14th Annual Teaching Course

Open Access

Evaluation of hepatic flow changes in early stages after extended hepatectomy by contrast enhanced ultrasound

  • N Fard1Email author,
  • N Rezaei1,
  • G Emmami1,
  • A Saffari1,
  • M Golriz1,
  • A Mehrabi1,
  • H-P Schlemmer1 and
  • S Delorme1
Cancer Imaging201414(Suppl 1):P35

https://doi.org/10.1186/1470-7330-14-S1-P35

Published: 9 October 2014

Background

Extended hepatectomy (EH) is the only curative procedure in patients with large or multi-nodular liver tumours. However, the alterations of the hepatic inflow (HF) after EH and the consequent complications like “small for size syndrome” (SFSS) are still challenging issues. Contrast-enhanced ultrasound (CEUS) is a non-invasive approach to evaluate liver haemodynamics with the advantages of imaging very low blood flow rates at the tissue perfusion level. The aim of this study is to detect the haemodynamic alterations after EH in early stage by CEUS in an experimental setting.

Method

An in vivo procaine model was studied using a low mechanical index in conjunction with single-level dynamic CEUS. A sulfur hexafluoride contrast agent (SonoVue; Bracco SpA, Milan, Italy) was applied in 5 pigs by intravenous bolus injection. Data were acquired before and after up to 75% sequential liver resections. Corresponding parameters of the time-intensity curve were measured using wash-in/wash-out curve software (Vuebox; Bracco SpA, Milan, Italy).

Result

Following sequential liver resection, the total HF increased gradually. In detail, the hepatic artery flow decreased 17% and portal vein flow increased around 70% after extended liver resection (75%). Also, with sequential liver resection, the PVP increased gradually up to 33% after extended liver resection (75%).

Conclusion

Quantitative and qualitative measurement of THF alteration in early stages is feasible by CEUS. CEUS is a suitable modality for follow-up control after EH in order to prevent postoperative complications such as SFSS, which lead to liver failure.

Authors’ Affiliations

(1)
German Cancer Research Center, Department of Surgery, Heidelberg University

Copyright

© Fard et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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