Volume 14 Supplement 1
Value of FDG PET/CT in the assessment of patients with colon cancer comparing to stand-alone CT
© Kaveh et al; licensee BioMed Central Ltd. 2014
Published: 9 October 2014
To evaluate the potential of FDG PET/CT vs. stand-alone CT in the assessment of histopathologically verified colon cancer in primary staging, re-staging and follow up.
Material and methods
patients (39 men, 31 women, mean age 70.7 ± 10.7 years) were included in this retrospective study: 28 (40%) primary staging, 28 (40%) re-staging and 14 (20%) follow-up patients.
Fifty-eight (58/70) patients (83%) had a primary tumour stage of ≥ T3. Patients with a known secondary carcinoma were excluded. Diagnostic contrast-enhanced CT was available in all patients (together with PET or in a separate setting with the same acquisition parameters).
The CT and FDG PET reports were examined for all patients. In discordant cases, images of both modalities were re-evaluated by a radiologist and a specialist in nuclear medicine separately.
All results were verified with histological findings or imaging and/or clinical follow-up studies for at least six months.
In the preoperative setting, additional FDG PET had an influence on the staging in 11 (11/28) patients (39%) comparing to CT alone:
Nine (9/28) patients (32%) were downstaged, 6 of them with suspicious organ metastases, 3 patients with suspicious lymph node metastases and 1 patient with both suspicious organ metastases and lymph nodes metastases on CT.
Two (2/28) patients (7%) were upstaged by FDG PET/CT, one of them with an unclear lung lesion on CT and a malignant hilar lymph node. The second patient showed peritoneal carcinosis on FDG PET.
Comparing with stand-alone CT, only 3 (3/42) patients (7%) from the restaging and follow-up group were downstaged by additional FDG PET, while concordant findings were seen on both imaging modalities for the rest of the patients.
This study clearly showed that for primary staging of distant metastases in colon cancer patients FDG PET/CT is more advantageous and overcomes the lower specificity of CT alone.
Comparing both modalities in postoperative cases, FDG PET provides additional findings only in few cases.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.