Staging of lymphoma under chimeric antigen receptor T-cell therapy: reasons for discordance among imaging response criteria

Table 3 Reasons for Classification of Progressive Disease According to Criteria

Criteria	TL PD	Focality of Progressive Lesions			NTL PD	NL PD				New Organ Lesion	PMD
Criteria	TL PD	Uni	Oligo	Multi	NTL PD	Total	Nodal	Extra-nodal	Both	New Organ Lesion	PMD
Lugano	10	4	1	5	3	7	2	1	4	Bone (3) Muscle (3) Peritoneal (2) Fat tissue Kidney Liver Lung Pancreas Pleura	2
Cheson	10	4	1	5	3	7	2	1	4		0
RECIL	7	1	1	5	0	7	2	1	4		0
LYRIC	6	0	1	5	1	6	1	1	4		0

Comparison of different imaging response criteria and the reasons for progressive disease. Shown are patient numbers with uni, oligo or multi target lesion (TL) progression, non-target lesion (NTL) progression, appearance of new lesions (NL) and progressive metabolic disease (PMD). Overlap of progression by multiple causes occurred in 53.8% of progressive patients by Lugano criteria, in 54.5% of patients by Cheson criteria, in 57.1% by RECIL, and 85.7% by LYRIC.

ISSN: 1470-7330