Staging of lymphoma under chimeric antigen receptor T-cell therapy: reasons for discordance among imaging response criteria

Table 2 PFS, OS Association, Absolute and Relative DoR at 30d and 90d According to Criteria

Criteria	Baseline TB	FU1 TB	FU2 TB	Median PFS	PFS-OS Association	DoR FU1 (30d)	DoR FU2 (90d)
Lugano	4,835 mm²	1,265 mm²	1,101 mm²	153 d	r = 0.499 p = 0.03	-60.5	-78.1%
Lugano	4,835 mm²	1,265 mm²	1,101 mm²	153 d	r = 0.499 p = 0.03	-2,284 mm²	-2,338 mm²
Cheson	4,835 mm²	1,265 mm²	1,101 mm²	169 d	r = 0.476 p = 0.03	-60.5	-78.1%
Cheson	4,835 mm²	1,265 mm²	1,101 mm²	169 d	r = 0.476 p = 0.03	-2,284 mm²	-2,338 mm²
RECIL	14.0 cm	7.5 cm	6.8 cm	198 d	r = 0.535 p = 0.01	-41.7	-48.4%
RECIL	14.0 cm	7.5 cm	6.8 cm	198 d	r = 0.535 p = 0.01	-4.3 cm	-6.1 cm
LYRIC	4,835 mm²	1,265 mm²	1,101 mm²	200 d	r = 0.758 p < 0.001	-60.5%	-78,1%
LYRIC	4,835 mm²	1,265 mm²	1,101 mm²	200 d	r = 0.758 p < 0.001	-2,284 mm²	-2,338 mm²

Patient characteristics showing tumor burden (TB) at baseline (BL), follow-up 1 (FU1), and FU2. Median progression-free survival (PFS) is shown in days (d). The association of PFS and OS is presented as Pearson’s r. Both absolute and percentage depth of response (DoR) are reported according to each response criterion

ISSN: 1470-7330