Fig. 2

MEMRI of control and GBM rats, 24 h after Mn²⁺ administration, under fed or fasted conditions. A Anatomical location of the slice selected, including the perimeters of the investigated ROIs in the left contralateral hemisphere: cortex (red), hippocampus (green), thalamus (blue) and hypothalamus (orange). B Representative T₁ maps of a control and a tumor-bearing animal, 24 h after Mn.²⁺ administration, under fed and fasted conditions. The ROIs (cortex, hippocampus, hypothalamus and thalamus) are outlined in the maps. C-F Boxplots of T₁ values from the different ROIs investigated, in control and GBM rats, under fed and fasted conditions. Box plots are represented as indicated in Fig. 1. Outliers are plotted individually using the '•' symbol. (* p-value < 0.05, *** p-value < 0.001)