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Table 1 Patient and tumor characteristics

From: Outcome of patients with biochemical recurrence of prostate cancer after PSMA PET/CT-directed radiotherapy or surgery without systemic therapy

Characteristic

Surgery (N = 30)

Radiotherapy (N = 28)

Age at diagnosis (years), median (range)

62.5 (49–73)

65 (47–73)

Initial Gleason score

 6

2 (6.67%)

6 (21.43%)

 3 + 4

8 (26.67%)

3 (10.71%)

 4 + 3

11 (36.67%)

12 (42.86%)

 8

4 (13.33%)

1 (3.57%)

 9

5 (16.67%)

6 (21.43%)

Primary tumor classification

 p/cT1

0 (0%)

5 (17.86%)

 p/cT2

11 (36.67%)

8 (28.57%)

 p/cT3

19 (63.33%)

15 (53.57%)

Primary nodal status

 p/cN0

25 (83.33%)

20 (71.43%)

 p/cN1

1 (3.33%)

2 (7.14%)

 p/cNx

4 (13.33%)

6 (21.43%)

Prior treatment

 RP

7 (23.33%)

7 (25.00%)

 RT

8 (26.67%)

11 (39.29%)

 RP + RT

15 (50.00%)

10 (35.71%)

Adjuvant ADT prior to PET/CT

16 (53.33%)

10 (35.71%)

D’Amico Score

 High risk

26 (86.67%)

17 (60.71%)

 Intermediate risk

4 (13.33%)

6 (21.43%)

 Low risk

0 (0%)

5 (17.86%)

Time from diagnosis to PET/CT (years), median (range)

6.5 (1–19)

7.5 (1–17)

Age at PET/CT (years), median (range)

71.5 (62–79)

73.5 (50–81)

PSA at PET/CT (ng/ml), median (range)

2.39 (0.44–17.8)

2.42 (0.46–9.32)

PSA-DT at PET/CT (mo), median (range)

5.6 (1.2–156)

8.4 (0.7–55)

Number of lesions at PET/CT

 1

16 (53.33%)

24 (85.71%)

 2

8 (26.67%)

3 (10.71%)

 3–5

6 (20.00%)

1 (3.57%)

Site of lesion

Na = 54

Nb = 33

 Local recurrence

7 (12.96%)

9 (27.27%)

 Regional lymph node

42 (77.78%)

12 (36.36%)

 Distant lymph node

3 (5.56%)

3 (9.09%)

 Bone

2 (3.70%)

9 (27.27%)

SULmax sum, median (range)

16.41 (2.51–68.95)

6.17 (2.60–74.15)

MTV sum, median (range)

3.38 (1.11–13.89)

2.26 (1.00–29.21)

TLG sum, median (range)

14.16 (1.23–236.12)

7.19 (0.91–281.23)

  1. RP radical prostatectomy, RT radiation therapy, ADT androgen deprivation therapy, PET/CT positron emission tomography/computed tomography, PSA Prostate specific antigen, PSA-DT prostate-specific antigen doubling time, SULmax maximum standardized uptake value normalized to lean body mass, MTV metabolic tumor volume, TLG total lesion glycolysis
  2. aTotal number of lesions in the PET-directed surgery group
  3. bTotal number of lesions in the PET-directed radiotherapy group