Table 3 Comparative analysis of CEUS characteristics of benign and malignant ductal lesions

No blood perfusion

3

1

Blood perfusion

41

37

 Wash in

12.062

 < 0.001^*

  Earlier

20(48.8)

33(89.2)

  Later

9(22.0)

0(0)

  Synchronous

12(29.3)

4(10.8)

 Wash out

1.417

0.492

  Earlier

20(48.8)

22(59.5)

  Later

10(26.8)

9(24.3)

  Synchronous

11(24.4)

6(16.2)

 Enhancement intensity

15.386

 < 0.001^*

  Hyper

18(43.9)

32(86.5)

  Hypo

12(29.3)

3(8.1)

  Iso

11(26.8)

2(5.4)

 Enhancement mode

5.701

0.017^*

  Homogeneous

22(53.7)

10(27)

  Heterogeneous

19(46.3)

27(73)

 Enhancement scope

40.592

 < 0.001^*

  Enlarged

3(7.3)

29(78.4)

  Not enlarged

38(92.7)

8(21.6)

 Blood perfusion defects

12.947

 < 0.001^*

  Presence

4(2.8)

17(45.9)

  Absence

37(90.2)

20(54.1)

 Peripheral high enhancement

24.28

 < 0.001^*

  Presence

3(7.3)

22(59.5)

  Absence

38(92.7)

15(40.5)

 Radial-penetrating vessels

2.10

0.147

  Presence

4(9.8)

8(28.6)

  Absence

37(90.2)

29(78.4)

 Boundary

18.56

 < 0.001^*

  Clear

30(73.2)

9(24.3)

  Unclear

11(26.8)

28(75.7)

 Quantitative parameters

  AT

11.3 ± 7.01

8.27 ± 2.25

2.652

0.011*

  k

2.2 ± 3.8

2.2 ± 0.87

0.021

0.984

  TTP

26.1 ± 27.8

18.4 ± 11.7

1.261

0.111

  PI

20.7 ± 82.4

10.7 ± 4.7

0.738

0.463

  AUC

477.66 ± 364.46

760.38 ± 478.79

-2.95

0.040*

  MTT

37.56 ± 25.74

30.78 ± 12.25

1.50

0.137