Cancer Imaging

Table 6 Univariate and multivariate survival analysis

From: Comparative analysis of different response criteria at early phase after PD-1 blockade in non-small lung cancer

Different variables	SUL_peak						MTV						TLG
	PFS			OS			PFS			OS			PFS			OS
	UV		MV	UV		MV	UV		MV	UV		MV	UV		MV	UV		MV
	MST	p	p	MST	p	p	MST	p	p	MST	p	p	MST	p	p	MST	p	p
Age
< 75	168			NR	0.645		168			NR			168			168
≥ 75	188	0.344		537			188	0.344		537	0.645		188	0.344		188	0.344
Sex
Male	174			759			174			759			174			174
Female	196	0.932		NR	0.499		196	0.932		NR	0.499		196	0.932		196	0.932
PS
0–1	239			NR			239			NR			239			239
2	65	0.079		235	0.004	0.014	65	0.079		235	0.004	0.016	65	0.079		65	0.079
Histology
AD	178			759			178			759			178			178
Non-AC	205	0.889		396	0.447		205	0.889		396	0.447		205	0.889		205	0.889
RECIST
Res	393			NR			393			NR			393			393
NRes	174	0.494		759	0.908		174	0.494		759	0.908		174	0.494		174	0.494
Uncontrol	105			NR			105			NR			105			105
Control	239	0.016	0.632	539	0.807	0.741	239	0.016	0.208	539	0.807		239	0.016	0.935	239	0.016	0.935
irRECIST
Res	393			NR			393			NR			393			393
NRes	174	0.494		759	0.908		174	0.494		759	0.908		174	0.494		174	0.494
Uncontrol	95			NR			95			NR			95			95
Control	239	0.001	0.436	537	0.636		239	0.001	0.070	537	0.636		239	0.001	0.589	239	0.001	0.589
PERCIST
Res	386			537			393			NR			355			355
NRes	144	0.066		759	0.954		138	0.105		514	0.136		133	0.119		133	0.119
Uncontrol	230			NR			108			371			105			105
Control	178	0.705		537	0.459		566	< 0.001	0.021	NR	0.035	0.770	393	< 0.001	0.115	393	< 0.001	0.115
iPERCIST
Res	393			NR			393			NR			355			355
NRes	133	0.016	0.040	514	0.288	0.208	138	0.105		514	0.136		133	0.119		133	0.119
Uncontrol	174			NR			95			371			79			79
Control	188	0.987		537	0.633		393	< 0.001	0.761	NR	0.030	0.960	355	< 0.001	0.942	355	< 0.001	0.942
EORTC
Res	355			NR			393			NR			393			393
NRes	165	0.109		759	0.874		129	0.064		514	0.156		125	0.035	0.958	125	0.035	0.958
Uncontrol	239			NR			111			372			95			95
Control	168	0.712		759	0.907		393	0.001	0.038	NR	0.057		355	< 0.001	0.749	355	< 0.001	0.749

Abbreviations: SUL_peak The peak standardized uptake value normalized by lean body mass, MTV Metabolic tumor volume, TLG Total lesion glycolysis, PFS Progression-free survival, OS Overall survival, UV Univariate analysis, MV Multivariate analysis, MST Median survival time (days), p. P-value, PS Performance status, AD Adenocarcinoma, Non-AD Non-adenocarcinoma, Res Responder, NRes Non-responder, NR Not reached, Uncontrol Uncontrolled disease, Control Controlled disease, bold types Statistically significance

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