18F-FDG PET-based criteria | CT-based criteria | |||||
---|---|---|---|---|---|---|
Response | PERCIST | iPERCIST | EORTC | Response | RECIST 1.1 | iRECIST |
CMR | Complete resolution of 18F-FDG uptake within TLs and disappearance of all other lesions to background | As per PERCIST | As per RECIST 1.1 | CR | Disappearance of all TLs and NTLs, all LNs < 10 mm in short-axis diameter | As per RECIST 1.1 |
PMR | > 30% relative reduction and > 0.8 absolute decrease in SULpeak of hottest lesion | Reduction in sum of SULpeak by at least 30% | After 1 cycle; > 15% of reduction After ≥2 cycle; > 25% of reduction | PR | > 30% decrease in SOM, no new lesions | As per RECIST 1.1 |
SMD | Neither CMR, PMR, nor PMD | As per PERCIST | Neither CMR, PMR, nor PMD | SD | Neither CR, PR, nor PD | As per RECIST 1.1 |
PMD | > 30% relative increase and > 0.8 absolute increase in SULpeak of hottest lesions and unequivocal progression of 18F-FDG uptake NTLs or new 18F-FDG uptake lesion | Unconfirmed PMD of > 30% relative increase needs to be confirmed by > 30% increase at 4 weeks later | > 25% increase of SUV | PD | > 20% increase in SOM of TLs or unequivocal progression of NTLs, or appearance of new lesion | PD by RECIST 1.1 in iUPD needs to be confirmed by follow-up examination of 4-8 weeks |