|  | Univariate analysis | Multivariate Analysis | |||
---|---|---|---|---|---|---|
MHLN (n = 31) | NHLN (n = 21) | P value | OR (95% confidence interval) | P value | ||
Gender | male/female | 8/23 | 4/17 | 0.741 | Â | Â |
Age |  | 52.90 ± 9.71 | 52.76 ± 8.58 | 0.141 |  | |
BMI |  | 24.51 ± 3.21 | 24.16 ± 2.86 | 0.358 |  | |
Primary location | Right−/left-side | 7/24 | 4/17 | > 0.999 |  | |
Differentiation | Low to moderate/High | 30/1 | 20/1 | > 0.999 |  | |
T stage of primary tuomor | T1 + 2/T3 + 4 | 1/30 | 4/17 | 0.145 |  | |
N stage of primary tuomor | N0/N+ | 3/28 | 1/20 | 0.639 | Â | |
Gene | RAS-wild | 20 | 12 | 0.540 | Â | |
RAS-mutation | 11 | 8 | ||||
Braf-mutation | 0 | 1 | ||||
Simultaneous liver metastases | No/Yes | 6/25 | 7/14 | 0.253 | Â | |
Distribution | Solitary/Bilateral | 8/23 | 7/14 | 0.557 | Â | |
Number of CRLM | ≤5/>5 | 10/21 | 13/8 | 0.277 |  | |
Size (mm) |  | 43.00 ± 30.89 | 43.43 ± 26.44 | 0.958 |  | |
RECIST evaluation | Response/Non- Response | 21/10 | 10/11 | 0.147 | Â | |
pre-CEA | 5 ng/ml | 4/24 | 4/15 | 0.697 |  | |
pre-CA199 | U/ml | 11/17 | 5/14 | 0.357 | Â | |
post-CEA | 5 ng/ml | 12/19 | 7/14 | 0.693 |  | |
post-CA199 | U/ml | 18/11 | 11/8 | 0.772 | Â | |
Shape of HLN | Regular/Irregular | 26/5 | 17/4 | > 0.999 |  | |
Signal intensity of HLN | Homogeneous/Hetergeneous | 28/3 | 13/8 | 0.019* | Â | |
Short axis of HLN at baseline | mm | 7.65 ± 2.79 | 9.86 ± 4.35 | 0.030* |  | |
Long axis of HLN at baseline | mm | 15.52 ± 6.74 | 17.14 ± 6.86 | 0.401 |  | |
Pre-ADCmean | mm2/s | 1528.06 ± 313.46 | 1490.95 ± 313.89 | 0.678 |  | |
Pre-ADCmin | mm2/s | 1115.45 ± 281.98 | 1096.86 ± 333.60 | 0.829 |  | |
Pre-rADC-lm |  | 1.24 ± 0.32 | 1.17 ± 0.25 | 0.411 |  | |
Pre-rADC-sp |  | 1.85 ± 0.37 | 1.79 ± 0.31 | 0.553 |  | |
Pre-rADC-m |  | 1.13 ± 0.23 | 1.09 ± 0.26 | 0.598 |  | |
Short axis of HLN at endpoint | mm | 6.77 ± 2.17 | 10.19 ± 3.19 | < 0.001* | 1.687(1.226-2.322) | 0.001* |
Long axis of HLN at endpoint | mm | 14.06 ± 6.32 | 17.81 ± 6.48 | 0.045* |  |  |
Post-ADCmean | mm2/s | 1649.90 ± 260.52 | 1435.86 ± 241.20 | 0.004* | 0.996(0.994-0.999) | 0.018* |
Post-ADCmin | mm2/s | 1228.77 ± 289.57 | 1075.24 ± 269.96 | 0.060 |  |  |
Post -rADC-lm |  | 1.29 ± 0.34 | 1.18 ± 0.28 | 0.239 |  |  |
Post -rADC-sp |  | 2.01 ± 0.40 | 1.81 ± 0.50 | 0.121 |  |  |
Post-rADC-m |  | 1.17 ± 0.24 | 1.03 ± 0.18 | 0.021* |  |  |
ΔADC |  | 9.65 ± 22.55 | 0.72 ± 27.10 | 0.203 |  |  |