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Table 2 Univariate and multivariate analysis of clinical and MRI factors for prediction of hilar lymph nodes in the training group

From: Prediction of hepatic lymph node metastases based on magnetic resonance imaging before and after preoperative chemotherapy in patients with colorectal liver metastases underwent surgical resection

  

Univariate analysis

Multivariate Analysis

MHLN (n = 31)

NHLN (n = 21)

P value

OR (95% confidence interval)

P value

Gender

male/female

8/23

4/17

0.741

  

Age

 

52.90 ± 9.71

52.76 ± 8.58

0.141

 

BMI

 

24.51 ± 3.21

24.16 ± 2.86

0.358

 

Primary location

Right−/left-side

7/24

4/17

> 0.999

 

Differentiation

Low to moderate/High

30/1

20/1

> 0.999

 

T stage of primary tuomor

T1 + 2/T3 + 4

1/30

4/17

0.145

 

N stage of primary tuomor

N0/N+

3/28

1/20

0.639

 

Gene

RAS-wild

20

12

0.540

 

RAS-mutation

11

8

Braf-mutation

0

1

Simultaneous liver metastases

No/Yes

6/25

7/14

0.253

 

Distribution

Solitary/Bilateral

8/23

7/14

0.557

 

Number of CRLM

≤5/>5

10/21

13/8

0.277

 

Size (mm)

 

43.00 ± 30.89

43.43 ± 26.44

0.958

 

RECIST evaluation

Response/Non- Response

21/10

10/11

0.147

 

pre-CEA

5 ng/ml

4/24

4/15

0.697

 

pre-CA199

U/ml

11/17

5/14

0.357

 

post-CEA

5 ng/ml

12/19

7/14

0.693

 

post-CA199

U/ml

18/11

11/8

0.772

 

Shape of HLN

Regular/Irregular

26/5

17/4

> 0.999

 

Signal intensity of HLN

Homogeneous/Hetergeneous

28/3

13/8

0.019*

 

Short axis of HLN at baseline

mm

7.65 ± 2.79

9.86 ± 4.35

0.030*

 

Long axis of HLN at baseline

mm

15.52 ± 6.74

17.14 ± 6.86

0.401

 

Pre-ADCmean

mm2/s

1528.06 ± 313.46

1490.95 ± 313.89

0.678

 

Pre-ADCmin

mm2/s

1115.45 ± 281.98

1096.86 ± 333.60

0.829

 

Pre-rADC-lm

 

1.24 ± 0.32

1.17 ± 0.25

0.411

 

Pre-rADC-sp

 

1.85 ± 0.37

1.79 ± 0.31

0.553

 

Pre-rADC-m

 

1.13 ± 0.23

1.09 ± 0.26

0.598

 

Short axis of HLN at endpoint

mm

6.77 ± 2.17

10.19 ± 3.19

< 0.001*

1.687(1.226-2.322)

0.001*

Long axis of HLN at endpoint

mm

14.06 ± 6.32

17.81 ± 6.48

0.045*

  

Post-ADCmean

mm2/s

1649.90 ± 260.52

1435.86 ± 241.20

0.004*

0.996(0.994-0.999)

0.018*

Post-ADCmin

mm2/s

1228.77 ± 289.57

1075.24 ± 269.96

0.060

  

Post -rADC-lm

 

1.29 ± 0.34

1.18 ± 0.28

0.239

  

Post -rADC-sp

 

2.01 ± 0.40

1.81 ± 0.50

0.121

  

Post-rADC-m

 

1.17 ± 0.24

1.03 ± 0.18

0.021*

  

ΔADC

 

9.65 ± 22.55

0.72 ± 27.10

0.203

  
  1. *P values that are significantly different between MHLN group and NHLN group