Amide Proton Transfer-weighted MRI combined with serum prostate-specific antigen levels for differentiating malignant prostate lesions from benign prostate lesions: a retrospective cohort study

Table 6 Analysis of the ROC curves of the combinations of different quantitative parameters

	AUC	95%CI	Sensitivity	Specificity	Youden index J	P value^a
APTmax + ADCmean	0.841	0.763–0.928	92.310	70.370	0.627	< 0.001
APTmax + PSAD	0.826	0.721–0.904	80.770	69.570	0.503	< 0.001
ADCmean + PSAD	0.854	0.753–0.925	75.000	91.300	0.663	< 0.001
APTmean + ADCmean	0.837	0.748–0.918	78.850	85.190	0.640	< 0.001
APTmean + PSAD	0.826	0.721–0.904	75.000	82.960	0.576	< 0.001
APTmean + ADCmean + PSAD	0.878	0.782–0.942	80.770	91.300	0.721	< 0.001
APTmax + APTmean + ADCmean + PSAD	0.880	0.784–0.943	86.540	78.260	0.648	< 0.001

ROC receiver operating characteristic, AUC area under the curve, CI confidence interval, APT amide proton transfer, ADC apparent diffusion coefficient, tPSA total prostate-specific antigen, FPSA free prostate-specific antigen, PSAD prostate-specific antigen density
^aDeLong et al., [21]

ISSN: 1470-7330