Amide Proton Transfer-weighted MRI combined with serum prostate-specific antigen levels for differentiating malignant prostate lesions from benign prostate lesions: a retrospective cohort study

Table 5 Analysis of the ROC curves of the different quantitative parameters

	AUC	95%CI	Sensitivity	Specificity	Youden index J	Best cut-off value	P value^a
APTmax	0.780	0.673–0.865	92.310	59.260	0.516	4.300	< 0.001
APTmean	0.710	0.598–0.807	63.460	77.780	0.412	2.300	0.001
ADCmean	0.793	0.688–0.876	75.000	81.480	0.565	1.060	< 0.001
ADCmax	0.689	0.575–0.788	46.150	92.580	0.388	1.360	0.002
ADCmin	0.689	0.575–0.789	73.080	70.370	0.435	0.620	0.003
tPSA	0.734	0.628–0.836	57.690	91.300	0.490	28.140	< 0.001
FPSA	0.684	0.565–0.788	42.000	100.000	0.420	7.240	0.003
FPSA/tPSA	0.684	0.565–0.788	68.000	69.570	0.376	17.050	0.007
PSAD	0.700	0.594–0.809	53.850	95.650	0.495	8.210	< 0.001

ROC receiver operating characteristic, AUC area under the curve, CI confidence interval, APT amide proton transfer, ADC apparent diffusion coefficient, tPSA total prostate-specific antigen, FPSA free prostate-specific antigen, PSAD prostate-specific antigen density
^aDeLong et al., [21]

ISSN: 1470-7330