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Table 5 Cox proportional hazards analysis for disease-free survival of ccRCC patients with VTT after nephrectomy and thrombectomy

From: Diagnostic performance and prognostic value of preoperative 18F-FDG PET/CT in renal cell carcinoma patients with venous tumor thrombus

Variable

Number(%)

Univariate

Forward Stepwise Multivariate

HR

95% CI

P value

HR

95% CI

P value

Clinicopathological parameters

 Age (years)

   

0.329

   

   ≥ 60

16(44.4)

0.619

0.237–1.620

    

   < 60

20(55.6)

1.000(ref.)

     

 Gender

   

0.352

   

  Male

29(80.6)

0.580

0.184–1.828

    

  Female

7(19.4)

1.000(ref.)

     

 Symptoms

   

0.510

   

  Presence

31(86.1)

1.642

0.376–7.180

    

  Absence

5(13.9)

1.000(ref.)

     

 BMI (kg/m2)

   

0.896

   

   ≥ 24.00 kg/m2

28(77.8)

0.928

0.304–2.834

    

   < 24.00 kg/m2

8(22.2)

1.000(ref.)

     

 Level of VTT

   

0.802

   

  Advanced

5(13.9)

1.174

0.337–4.090

    

  Early

31(86.1)

1.000(ref.)

     

 WHO/ISUP grade

   

0.038

   

  G3/G4

25(69.4)

4.760

1.092–20.742

    

  G1/G2

11(30.6)

1.000(ref.)

     

PET/CT parameters

 Distant metastasis

   

0.012

  

0.013

  Presence

14(38.9)

3.382

1.307–8.751

 

3.344

1.293–8.649

 

  Absence

22(61.1)

1.000(ref.)

  

1.000(ref.)

  

 Primary tumor SUVmax

   

0.081

   

   ≥ 4.45

22(61.1)

2.704

0.885–8.255

    

   < 4.45

14(38.9)

1.000(ref.)

     

 VTT SUVmax

   

0.017

  

0.018

   ≥ 4.30

11(30.6)

3.167

1.227–8.174

 

3.123

1.212–8.044

 

   < 4.30

25(69.4)

1.000(ref.)

  

1.000(ref.)

  

 Primary tumor size (cm)

   

0.634

   

   ≥ 8.65

18(50.0)

0.797

0.313–2.030

    

   < 8.65

18(50.0)

1.000(ref.)

     
  1. Abbreviations: ccRCC clear cell renal cell carcinoma, BMI body mass index, VTT venous tumor thrombus, WHO/ISUP World Health Organization/the International Society of Urological Pathology, PET/CT positron emission tomography/computed tomography, SUVmax maximum standardized uptake value
  2. P value < 0.05 was highlighted using italic font