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Table 2 Patient and PET parameters for the normal thyroid (n = 30) and hypothyroid (n = 22) groups

From: Early post-treatment 18F-FDG PET/CT for predicting radiation-induced hypothyroidism in head and neck cancer

Characteristic

Normal

Hypothyroid

p value

Patient factor

   

 Age (years)

53.6 (9.6)

50.0 (10.1)

0.209

 Male sex, n (%)

23 (76.7%)

16 (72.7%)

1.000

 Pretreatment thyroid volume (cm3)

17.9 (6.6)

12.1 (4.7)

0.001 *

 Mean radiotherapy dose to thyroid (Gy)

40.9 (10.6)

48.6 (8.4)

0.007 *

 Mean radiotherapy dose to pituitary (Gy)

42.8 (24.6)

43.4 (27.6)

0.937

Early post-treatment PET parameter

   

 Thyroid SUVmax

2.57 (1.41)

2.35 (0.69)

0.511

 Thyroid SUVmean

1.89 (0.87)

1.80 (0.45

0.680

 Thyroid TLG

14.10 (8.27)

11.04 (7.09)

0.167

 Thyroid functioning volume, cm3

16.30 (6.03)

10.61 (3.81)

< 0.001 *

 Blood pool SUVmax

2.10 (0.41)

2.06 (0.36)

0.688

 Thyroid SUVmax/blood pool SUV ratio

1.15 (0.20)

1.17 (0.32)

0.752

 Pituitary SUVmax

2.76 (0.54)

2.81 (0.46)

0.712

 Pituitary SUVmean

2.38 (0.48)

2.36 (0.34)

0.861

  1. Abbreviations: PET, positron emission tomography; SUV, standardized uptake value; TLG, total lesion glycolysis. *, p < 0.05