Table 1 Characteristics of patients in the primary and validation cohorts
Characteristic | Primary cohort | P | Validation cohort | P | ||
|---|---|---|---|---|---|---|
non-fistula | fistula | non-fistula | fistula | |||
Gender (%) | 0.185 | 0.307 | ||||
Male | 68 (90.67) | 27 (100) | 69 (92) | 23 (85.19) | ||
Female | 7 (9.33) | 0 (0) | 6 (8.0) | 4 (14.81) | ||
Age, mean ± SD, years | 60.62 ± 8.05 | 59.07 ± 7.26 | 0.38 | 60.54 ± 8.04 | 58.78 ± 7.82 | 0.353 |
Grade (%) | 0.125 | 0.881 | ||||
Mid-high | 43 (57.33) | 20 (74.07) | 46 (61.33) | 17 (62.96) | ||
Low | 32 (42.67) | 7 (25.93) | 29 (38.67) | 10 (37.04) | ||
Location (%) | 0.004 | 0.09 | ||||
Neck | 4 (5.33) | 1 (3.70) | 6 (8.0) | 1 (3.70) | ||
Upper-thorax | 14 (18.67) | 2 (7.41) | 14 (18.67) | 6 (22.22) | ||
Mid-thorax | 29 (38.67) | 21 (77.78) | 31 (41.33) | 17 (62.96) | ||
Low-thorax | 28 (37.33) | 3 (11.11) | 24 (32.0) | 3 (11.11) | ||
Treatment (%) | 0.822 | 0.610 | ||||
Chemotherapy | 37 (49.33) | 14 (51.85) | 32 (42.67) | 10 (37.04) | ||
Chemoradiotherapy | 38 (50.67) | 13 (48.15) | 43 (57.33) | 17 (62.96) | ||
T stage (%) | < 0.001 | 0.059 | ||||
T1 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
T2 | 9 (12) | 0 (0) | 7 (9.33) | 1 (3.70) | ||
T3 | 61 (81.33) | 12 (44.45) | 59 (78.67) | 17 (62.97) | ||
T4a | 0 (0) | 1 (3.70) | 1 (1.33) | 3 (11.11) | ||
T4b | 5 (6.67) | 14 (51.85) | 8 (10.67) | 6 (22.22) | ||
Trachea invasion (%) | < 0.001 | 0.5 | ||||
No | 73 (97.33) | 15 (55.56) | 67 (89.33) | 23 (85.19) | ||
Yes | 2 (2.67) | 12 (44.44) | 8 (10.67) | 4 (14.81) | ||
N stage (%) | 0.321 | 0.021 | ||||
No | 5 (6.67) | 0 (0) | 8 (10.67) | 0 (0) | ||
Yes | 70 (93.33) | 27 (100) | 67 (89.33) | 27 (100) | ||
Metastasis (%) | 0.387 | 0.55 | ||||
No | 60 (80) | 24 (88.89) | 62 (82.67) | 24 (88.89) | ||
Yes | 15 (20) | 3 (11.11) | 13 (17.33) | 3 (11.11) | ||
Tumor range(%) | < 0.001 | 0.025 | ||||
0–1/4 | 1 (1.34) | 0 (0) | 0 (0) | 0 (0) | ||
1/4–1/2 | 18 (24.0) | 0 (0) | 11 (14.67) | 1 (3.70) | ||
1/2–3/4 | 25 (33.33) | 2 (7.41) | 30 (40.0) | 6 (22.22) | ||
3/4–1 | 31 (41.33) | 25 (92.59) | 34 (45.33) | 20 (74.07) | ||
Type (%) | 0.195 | 0.952 | ||||
Focal | 17 (22.67) | 3 (11.11) | 19 (25.33) | 7 (25.93) | ||
Diffuse | 58 (77.33) | 24 (88.89) | 56 (74.67) | 20 (74.07) | ||
Luminal obliteration (%) | 0.303 | 0.634 | ||||
No | 25 (33.33) | 12 (44.44) | 26 (34.67) | 8 (29.63) | ||
Yes | 50 (66.67) | 15 (55.56) | 49 (65.33) | 19 (70.37) | ||
Deep ulcer(%) | < 0.001 | < 0.001 | ||||
No | 70 (93.33) | 5 (18.52) | 66 (88.0) | 9 (33.33) | ||
Yes | 5 (6.67) | 22 (81.48) | 9 (12.0) | 18 (66.67) | ||
THK-tumor (mm) | 14.73 ± 4.99 | 17.89 ± 5.07 | 0.006 | 15.29 ± 6.33 | 17.44 ± 5.90 | 0.118 |
L-tumor (mm) | 54.20 ± 20.86 | 81.67 ± 26.19 | < 0.001 | 54.73 ± 22.97 | 75.19 ± 28.15 | < 0.001 |
DEP-ulcer (mm) | 0.61 ± 2.40 | 10.46 ± 6.89 | < 0.001 | 0.96 ± 2.73 | 6.59 ± 5.73 | < 0.001 |
THK-residue (mm) | 14.16 ± 5.20 | 9.54 ± 3.96 | < 0.001 | 13.91 ± 6.76 | 9.70 ± 7.86 | 0.002 |
THK-adjacency (mm) | 14.59 ± 4.83 | 16.54 ± 4.96 | 0.082 | 14.93 ± 6.20 | 15.63 ± 5.85 | 0.392 |
R-ulcer (%) | 5.07 ± 19.65 | 68.98 ± 52.67 | < 0.001 | 6.42 ± 18.21 | 46.12 ± 37.47 | < 0.001 |
R-residue (%) | 96.67 ± 13.07 | 43.75 ± 28.42 | < 0.001 | 93.15 ± 19.08 | 59.01 ± 33.54 | < 0.001 |
HU-min (HU) | 43.86 ± 16.34 | 26.33 ± 13.55 | < 0.001 | 45.17 ± 17.32 | 30.52 ± 13.15 | < 0.001 |
THK-min (mm) | 11.13 ± 4.55 | 13.93 ± 4.66 | 0.003 | 11.35 ± 5.29 | 12.41 ± 5.21 | 0.202 |
R-min | 0.77 ± 0.19 | 0.79 ± 0.17 | 0.939 | 0.75 ± 0.17 | 0.74 ± 0.25 | 0.802 |
HU-max (HU) | 93.75 ± 14.29 | 90.53 ± 12.75 | 0.286 | 94.28 ± 15.45 | 85.61 ± 12.89 | 0.006 |
THK-max (mm) | 11.15 ± 3.81 | 13.89 ± 4.93 | 0.01 | 10.88 ± 3.78 | 12.00 ± 2.76 | 0.068 |
R-HU | 0.47 ± 0.17 | 0.30 ± 0.14 | < 0.001 | 0.48 ± 0.17 | 0.36 ± 0.15 | 0.002 |