Fig. 3.

78-year-old man presents with PSA 15.90 ng/mL and PSA density 0.14 ng/mL² for PET-targeted HIFU of a PI-RADS 5 lesion in the right posterior apex. Pre-therapy ⁶⁸ Ga-PSMA11 A and ⁶⁸ Ga-RM2 C axial PET, axial fused PET/MRI, MRI, and MIP images show concordant focal uptake in the right posterior prostate (red arrows). After HIFU, ⁶⁸ Ga-PSMA11 B and ⁶⁸ Ga-RM2 D axial PET, axial fused PET/MRI, MRI, and MIP show structural changes with urine pooling in the treated area (blue arrows) but no pathologic uptake. Biopsy confirmed no evidence of PC in the treated area