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Table 2 HRs and CIs for PFS for the multivariate Cox PH model with imaging metrics and the multivariate Cox PH model with clinical variables only (training set)

From: Full automation of total metabolic tumor volume from FDG-PET/CT in DLBCL for baseline risk assessments

 

PFS

OS

 

HR

95% CI

P-value

C-Index

test set

AUC 2-years

test set

HR

95% CI

P-value

C-Index test set

AUC 2-years test set

Cox PH model with imaging metrics

 Hemoglobin < LLN

1.22

0.94–1.58

.13

  

1.37

0.99–1.89

.06

  

 ECOG PS > 1

1.26

0.89–1.78

.19

  

1.29

0.84–1.96

.24

  

 Ann Arbor stage IV

1.41

1.10–1.82

.007

  

1.49

1.08–2.04

.01

  

 aTMTV > Q3

1.31

0.98–1.74

.06

0.63

0.59

1.18

0.83–1.67

.35

0.62

0.61

 Number of lesions > 4 (median)

1.62

1.23–2.71

.0006

  

1.91

1.34–2.71

.0003

  

 Liver involvement

1.16

0.82–1.64

.40

  

1.03

0.68–1.58

.88

  

 LDH elevated

1.12

0.86–1.46

.39

  

1.30

0.93–1.82

.12

  

Cox PH model with clinical variables only

 Hemoglobin < LLN

1.40

1.09–1.80

.01

  

1.57

1.14–2.15

.005

  

 ECOG PS > 1

1.40

0.99–1.96

.05

0.59

0.57

1.39

0.92–2.10

.11

0.59

0.57

 Ann Arbor stage IV

1.61

1.26–2.05

.0001

  

1.68

1.24–2.28

.0009

  

 LDH elevated

1.30

1.01–1.68

.04

  

1.51

1.09–2.09

.01

  
  1. CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, HR Hazard ratio, LDH Lactate dehydrogenase, LLN Lower limit of normal, OS Overall survival, PFS Progression-free survival, PH Proportional hazard, Q3 Third quartile, TMTV Total metabolic tumor volume
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Cancer Imaging

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