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Table 1 Summary of the biologic pathways and their respective molecular imaging probes included in this review

From: Novel applications of molecular imaging to guide breast cancer therapy

Biochemical/Metabolic Target

Radiotracer/s

Glucose metabolism

18F-fluorodeoxyglucose (FDG)

Steroid Receptor Expression

 

 Estrogen Receptor

18F-fluoroestradiol (FES)

 Progesterone Receptor

18F-fluoronorpregnenedione (FFNP)

 Androgen Receptor

18F-fluorodihydrotestosterone (FDHT)

HER2 Receptor Expression

89Z-trastuzumab, 64Cu-DOTA-trastuzumab,18F-fluorobenzamidoethylmaleimide (FBEM)

Cell proliferation: Thymidine analog

18F-fluorothymidine (FLT)

Amino Acid transport and metabolism

18F-flurocyclobutane-1-carboxylic acid (18F-fluciclovine)18F-fluoroglutamine (18F-Gln)

Poly (ADP-ribose) polymerase-1 (PARP-1) expression

18F-FluorThanatrace