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Table 1 Dual tracer molecular imaging grading scales of neuroendocrine tumours

From: Molecular imaging phenotyping for selecting and monitoring radioligand therapy of neuroendocrine neoplasms

Study

Reference for positive lesion

Group

SSTR PET

18F-FDG PET

Suitability for PRRT

Chan et al. [29] (NETPET)

 > Background

(Modified Krenning score 2–4)

P0

Negative

Negative

Not suitable

P1

Positive

Negative

Probably suitable

P2

Positive

Positive (avidity on 18F-FDG < SSTR)

Probably suitable

P3

Positive

Positive (avidity on 18F-FDG = SSTR)

Probably suitable

P4

Positive

Positive (avidity on 18F-FDG > SSTR)

Probably suitable if P4aa; Maybe suitable with additional therapy required if P4b

P5

Negative

Positive

No

Karfis et al. [30]

 > Background

(Modified Krenning score 2–4)

C1

Positive (all lesions)

Negative (all lesions)

Probably suitable

C2

Positive (all lesions)

Positive (≥ 1 lesion)

Probably suitable

C3

Negative (≥ 1 lesion) b

Positive (≥ 1 lesion)

Not suitable

Zidan et al. [14]

 > Liver

(Modified Krenning score 3–4)

1

Negative (all lesions)

Negative (all lesions

Not suitable

2

Positive (all lesions)

Negative (all lesions)

Suitable

3

Positive (all lesions)

Positive (≥ 1 lesion)

Suitable

4

Negative (≥ 1 lesion)b

Positive (≥ 1 lesion)

Not suitable

  1. aa – 1–2 lesions; b – 3 or more lesions showing the grade-specific pattern of avidity
  2. b At least one of the.18F-FDG avid lesions is SSTR PET negative