Fig. 6From: Molecular imaging phenotyping for selecting and monitoring radioligand therapy of neuroendocrine neoplasmsA patient with small cell lung cancer with progression after platinum-based chemotherapy and immune checkpoint monoclonal antibodies. 68Ga-DOTATATE PET and PET/CT (A) showed extensive moderately avid (Krenning score 3) osteolytic bone metastases (arrows). In the absence of other treatment options, the patient underwent 177Lu-DOTATATE, and post-treatment SPECT and SPECT/CT at 24Â h (B) showed very high tracer retention (Krenning score 4), much higher than expected from baseline 68Ga-DOTATATE PET, in all sites of diseaseBack to article page