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Table 2 Characteristics of the eligible articles

From: Prognostic value of cervical nodal necrosis on staging imaging of nasopharyngeal carcinoma in era of intensity-modulated radiotherapy: a systematic review and meta-analysis

First author Year of Publication City Patient recruitment period Total patients Patients treated with chemotherapy Patients with nodes Patients with CNN Imaging modality Numbers of undifferentiated
+ non-keratinising types
AJCC /UICC Edition Median follow-up time in months (range) Patient group for analysis
CNN presence/absence in any nodal group
Li [19] 2013 Guangzhou 2003-2007 749 535 565 142 MRI 744 7th 60.7
(3-104)
N+ group
Zhang [20] 2017 Guangzhou 2009-2012 1302 1193 1302 448 MRI 1294 7th 47.8
(1.3-75.3)
N+ group
Zhou [21] 2018 Shanghai 2010-2011 354 300 320 143 MRI 353 7th 63
(Not mentioned)
All
Feng [22] 2019 Hangzhou 2007-2012 616 601 616 235 MRI 612 8th 62.6
(3.4 -119)
N+ group
Ai [23] 2019 Hong Kong 2005-2012 546 382 404 153 MRI 544 8th 82.3
(3.2-150)
N+ group
Xu [24] 2021 Xi’an 2006-2018 792 744 687 501 MRI 789 7th 46.2
(1.3-130)
All
CNN presence/absence in retropharyngeal nodes
Tang [25] 2014 Guangzhou 2003-2007 749 535 565 64/481 (RPN+) MRI 744 7th 81
(3-127)
N+ group
CNN grades
Zhang [26] 2017 Guangzhou 2009-2012 1423 1310 1423 Grade 1: 213
Grade 2: 257
MRI 1415 7th 48.6
(1.3-76)
N+ group
CNN laterality
Xie [27] 2020 Guangzhou 2010-2013 733 634 559 No/unilateral CNN: 692
Bilateral CNN: 41
MRI 728 8th 62
(1.4-83.2)
All
  1. CNN Cervical nodal necrosis, AJCC/UICC American Joint of Cancer Committee/ Union for International Cancer Control, N+group Patients with metastatic nodes, RPN Retropharyngeal node, MRI Magnetic resonance imaging