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Table 1 Results of univariate analyses of MRI and PET data. The Mann Whitney test was used to compare IDH1+ and IDH1- groups with significant, adjustedp values < 0.05 shown in bold

From: Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study

Static acquisitions

Dynamic acquisitions

Radio-tracers

IDH status

N

TBRmean

p

TBRmax

p

MTV (mm3)

p

N

DVR

p

RRT

p

[18F] FDG

IDH1+

N = 4

1.56 [1.46; 1.83]

0.91

1.37 [1.30; 1.54]

0.83

221.45 [176.60; 268.82]

0.96

IDH1-

N = 7

1.69 [1.61; 1.75]

1.45 [1.43; 1.48]

250.00 [174.15; 273.25]

[18F] FDopa

IDH1+

N = 13

2.86 [2.41; 3.36]

0.83

2.51 [2.07; 3.20]

0.83

29.00 [7.32; 220.70]

0.96

N = 8

2.63 [2.14; 3.74]

0.96

2.69 [1.45; 3.23]

0.02

IDH1-

N = 13

2.57 [2.51; 2.95]

2.21 [2.11; 2.62]

72.00 [23.50; 202.00]

N = 6

2.57 [2.45; 3.52]

−1.81 [−3.04; −0.74]

[18F] DPA-714

IDH1+

N = 7

4.48 [4.43; 4.67]

0.27

3.90 [3.29; 4.67]

0.03

48.50 [31.32; 56.60]

0.18

N = 7

5.28 [4.74; 5.49]

0.05

11.07 [7.08; 15.68]

< 0.01

IDH1-

N = 8

4.86 [4.66; 5.16]

5.52 [4.72; 6.72]

76.80 [68.60; 113.20]

N = 8

9.03 [6.82; 9.73]

22.33 [20.68; 23.76]