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Table 1 Results of univariate analyses of MRI and PET data. The Mann Whitney test was used to compare IDH1+ and IDH1- groups with significant, adjustedp values < 0.05 shown in bold

From: Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study

Static acquisitions Dynamic acquisitions
Radio-tracers IDH status N TBRmean p TBRmax p MTV (mm3) p N DVR p RRT p
[18F] FDG IDH1+ N = 4 1.56 [1.46; 1.83] 0.91 1.37 [1.30; 1.54] 0.83 221.45 [176.60; 268.82] 0.96
IDH1- N = 7 1.69 [1.61; 1.75] 1.45 [1.43; 1.48] 250.00 [174.15; 273.25]
[18F] FDopa IDH1+ N = 13 2.86 [2.41; 3.36] 0.83 2.51 [2.07; 3.20] 0.83 29.00 [7.32; 220.70] 0.96 N = 8 2.63 [2.14; 3.74] 0.96 2.69 [1.45; 3.23] 0.02
IDH1- N = 13 2.57 [2.51; 2.95] 2.21 [2.11; 2.62] 72.00 [23.50; 202.00] N = 6 2.57 [2.45; 3.52] −1.81 [−3.04; −0.74]
[18F] DPA-714 IDH1+ N = 7 4.48 [4.43; 4.67] 0.27 3.90 [3.29; 4.67] 0.03 48.50 [31.32; 56.60] 0.18 N = 7 5.28 [4.74; 5.49] 0.05 11.07 [7.08; 15.68] < 0.01
IDH1- N = 8 4.86 [4.66; 5.16] 5.52 [4.72; 6.72] 76.80 [68.60; 113.20] N = 8 9.03 [6.82; 9.73] 22.33 [20.68; 23.76]