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Table 2 Changes in the Child–Pugh scores, Child–Pugh stages

From: TIPS improves outcomes in patients with HCC and symptomatic portal hypertension: a multi-institution experience

Variable

Before TIPS

One month after TIPS

P

Response to TIPSb

 CR

 

92(74.8%)

 

 PR

 

23(18.7%)

 

 NR

 

8(6.5%)

 

Child–Pugh stage

  

0.006*

 A

32(26.0%)

56(45.5%)

 

 B

79(64.2%)

58(47.2%)

 

 C

12(9.8%)

9(7.3%)

 

Change of Child–Pugh stageb

 Down

 

41(33.3%)

 

 Unchanged

 

70(56.9%)

 

 Elevated

 

12(9.8%)

 

 Child–Pugh scores

8(6-9)

7(6-8)

<0.001**

Change of Child–Pugh scoresb

 Down

 

73(59.3%)

 

 Unchanged

 

28(22.8%)

 

 Elevated

 

22(17.9%)

 

HEa

  

1.000*

 I/II

4(3.3%)

12(9.8%)

 

 III/IV

0

1(0.8%)

 

Grading of ascites

 0/1

56(45.5%)

107(87.0%)

<0.001*

 2/3

67(54.5%)

16(13.0%)

 

Bilirubin(IQRa, umol/L)

29.5(19.2-41.0)

37.4(25.6-48.1)

<0.001**

 <34

75(61.0%)

51(41.4%)

 

 ≥34

48(39.0%)

72(58.6%)

 

Albumin (g/L)

33.2(30.2-36.8)

34.7(33.1-36.8)

0.134**

 <35

72(58.5%)

65(52.8%)

 

 ≥35

51(41.5%)

58(47.2%)

 

PT(s)a

14.2(13.1-15.6)

15.5(14.1-17.1)

<0.001**

 Prolonged < 6

117(95.1%)

71(57.7%)

 

 Prolonged ≥6

6(4.9%)

52(42.3%)

 
  1. aHE Hepatic encephalopathy, PT prothrombin time; bOne month after TIPS, the Child-Pugh stage and Child-Pugh score were reassessed. The responses to TIPS: complete response (CR), no further variceal bleeding and having no clinically detectable ascites with or without diuretic or salt-restricted diet; partial response (PR), having a small amount of ascites not requiring special paracentesis; and nonresponse (NR), having a large amount of ascites needing special intervention or variceal bleeding recurrence. *Chi-square test; **Paired t-test