Determining the elastography strain ratio cut off value for differentiating benign from malignant breast lesions: systematic review and meta-analysis

Mutala, Timothy Musila; Mwango, Gladys N.; Aywak, Angeline; Cioni, Dania; Neri, Emanuele

doi:10.1186/s40644-022-00447-5

Table 1 Study characteristics

From: Determining the elastography strain ratio cut off value for differentiating benign from malignant breast lesions: systematic review and meta-analysis

Study	Continent	Design	Number of Lesions	Setting	Index test (Strain Ratio) Measurement Method	Reference Standard	Target Condition Definition
Ahmed 2020 [14]	Africa	Prospective	132	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Alhabshi 2013 [15]	Asia	Prospective	168	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Arslan 2018 [16]	Europe	Retrospective	113	Imaging before biopsy	Not Clear	Mixed	Malignant Vs Benign
Balcik 2016 [17]	Europe	Prospective	135	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Bojanic 2017 [18]	Europe	Prospective	130	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Chee 1 2019 [19]	Asia	Prospective	53	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Chee 2 2019 [19]	Asia	Prospective	53	Imaging before biopsy	GLR	Mixed	Malignant Vs Benign
Cheng 2018 [20]	Asia	Prospective	37	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Cho 2010 [21]	Asia	Prospective	99	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Dawood 2018 [22]	Africa	Prospective	40	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Fausto 2015 [23]	Europe	Prospective	129	Imaging before biopsy	Mixed FLR and GLR	Core Biopsy	Malignant Vs Benign
Fujioka 2019 [24]	Asia	Retrospective	148	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Gheonea 2011 [25]	Europe	Prospective	58	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Gong 2013 [26]	Asia	Prospective	192	Imaging before biopsy	Not Clear	Mixed	Malignant Vs Benign
Graziano 1 2017 [27]	South America	Prospective	159	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Graziano 2 2017 [27]	South America	Prospective	159	Imaging before biopsy	GLR	Mixed	Malignant Vs Benign
Guruf 2019 [28]	Europe	Prospective	87	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Hao 2020 [29]	Asia	Prospective	311	Imaging before biopsy	GLR	Mixed	Malignant Vs Benign
Jung Hahn 2012 [30]	Asia	Retrospective	110	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Jung Park 1 2016 [31]	Asia	Prospective	358	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Jung Park 2 2016 [31]	Asia	Prospective	358	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Khamis 2017 [32]	Africa	Prospective	120	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Kim Kim 2018 [33]	Asia	Prospective	108	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Kumm 2010 [34]	North America	Prospective	310	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Lee 2011 [35]	Asia	Retrospective	315	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Li Wang 2015 [36]	Asia	Retrospective	89	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Liu 2014 [37]	Asia	Retrospective	431	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Mansour 2012 [38]	Africa	Prospective	97	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Menezes 2016 [39]	Asia	Prospective	143	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Mu 2016 [40]	Asia	Retrospective	1080	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Mutala 2016 [41]	Africa	Prospective	112	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Nakashima 2018 [42]	Asia	Prospective	232	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Ozel 2018 [43]	Europe	Prospective	297	Imaging before biopsy	Mixed FLR and GLR	Core Biopsy	Malignant Vs Benign
Ozsoy 2016 [44]	Europe	Prospective	168	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Parajuly 2012 [45]	Asia	Prospective	342	Imaging before biopsy	Not Clear	Mixed	Malignant Vs Benign
Park 1 2020 [46]	Asia	Retrospective	140	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Park 2 2020 [46]	Asia	Retrospective	140	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Park 3 2020 [46]	Asia	Retrospective	140	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Rehman 2017 [47]	Asia	Prospective	137	Imaging before biopsy	Not Clear	Core Biopsy	Malignant Vs Benign
Ricci 2017 [48]	Europe	Prospective	242	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Seo 2018 [49]	Asia	Prospective	45	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Singla 2019 [50]	Asia	Prospective	199	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Stachs 2013 [51]	Europe	Prospective	224	Imaging before biopsy	Not Clear	Not Clear	Malignant Vs Benign
Stoian 2016 [52]	Europe	Prospective	174	Imaging before biopsy	Not Clear	Surgical	Malignant Vs Benign
Thomas 2010 [53]	Europe	Prospective	227	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Turker 2017 [54]	Europe	Prospective	75	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Ueno 1 2015[55]	Asia	Prospective	98	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Ueno 2 2007 [56]	Asia	Not Clear	406	Imaging before biopsy	Not Clear	Not Clear	Malignant Vs Benign
Wang 2018 [57]	Asia	Prospective	302	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Yagci 2017 [58]	Europe	Prospective	68	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Yerli 2011[59]	Europe	Prospective	78	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Yildiz 2020 [60]	Europe	Prospective	50	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Yilmaz 2017 [61]	Europe	Prospective	79	Imaging before biopsy	FLR	Core Biopsy	Malignant Vs Benign
Yoon 1 2016 [62]	Asia	Prospective	201	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Yoon 2 2017 [63]	Asia	Prospective	243	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Yoon 3 2017 [63]	Asia	Prospective	243	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
You 2019 [64]	Asia	Retrospective	373	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Youk 2014 [65]	Asia	Retrospective	79	Imaging before biopsy	Not Clear	Mixed	Malignant Vs Benign
Zhang 1 2020 [66]	Asia	Prospective	91	Imaging before biopsy	Mixed FLR and GLR	Not Clear	Malignant Vs Benign
Zhang 2 2020 [66]	Asia	Prospective	91	Imaging before biopsy	Mixed FLR and GLR	Not Clear	Malignant Vs Benign
Zhao 2018 [67]	Asia	Retrospective	1071	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Zhi 2010 [68]	Asia	Prospective	559	Imaging before biopsy	Mixed FLR and GLR	Mixed	Malignant Vs Benign
Zhou 1 2014 [69]	Asia	Prospective	193	Imaging before biopsy	FLR	Mixed	Malignant Vs Benign
Zhou 2 2014 [69]	Asia	Prospective	193	Imaging before biopsy	GLR	Mixed	Malignant Vs Benign
Zhou 3 2014 [70]	Asia	Prospective	127	Imaging before biopsy	GLR	Mixed	Malignant Vs Benign

Key
1. FLR Fat to lesion ratio
2. GLR Glandular tissue to lesion ratio
3. Mixed Any combination including core needle biopsy (CNB), FNA cytology, surgical and resolution via follow up

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ISSN: 1470-7330

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