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Table 1 Study characteristics

From: Determining the elastography strain ratio cut off value for differentiating benign from malignant breast lesions: systematic review and meta-analysis

Study Continent Design Number of Lesions Setting Index test (Strain Ratio) Measurement Method Reference Standard Target Condition Definition
Ahmed 2020 [14] Africa Prospective 132 Imaging before biopsy FLR Mixed Malignant Vs Benign
Alhabshi 2013 [15] Asia Prospective 168 Imaging before biopsy FLR Mixed Malignant Vs Benign
Arslan 2018 [16] Europe Retrospective 113 Imaging before biopsy Not Clear Mixed Malignant Vs Benign
Balcik 2016 [17] Europe Prospective 135 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Bojanic 2017 [18] Europe Prospective 130 Imaging before biopsy FLR Mixed Malignant Vs Benign
Chee 1 2019 [19] Asia Prospective 53 Imaging before biopsy FLR Mixed Malignant Vs Benign
Chee 2 2019 [19] Asia Prospective 53 Imaging before biopsy GLR Mixed Malignant Vs Benign
Cheng 2018 [20] Asia Prospective 37 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Cho 2010 [21] Asia Prospective 99 Imaging before biopsy FLR Mixed Malignant Vs Benign
Dawood 2018 [22] Africa Prospective 40 Imaging before biopsy FLR Mixed Malignant Vs Benign
Fausto 2015 [23] Europe Prospective 129 Imaging before biopsy Mixed FLR and GLR Core Biopsy Malignant Vs Benign
Fujioka 2019 [24] Asia Retrospective 148 Imaging before biopsy FLR Mixed Malignant Vs Benign
Gheonea 2011 [25] Europe Prospective 58 Imaging before biopsy FLR Mixed Malignant Vs Benign
Gong 2013 [26] Asia Prospective 192 Imaging before biopsy Not Clear Mixed Malignant Vs Benign
Graziano 1 2017 [27] South America Prospective 159 Imaging before biopsy FLR Mixed Malignant Vs Benign
Graziano 2 2017 [27] South America Prospective 159 Imaging before biopsy GLR Mixed Malignant Vs Benign
Guruf 2019 [28] Europe Prospective 87 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Hao 2020 [29] Asia Prospective 311 Imaging before biopsy GLR Mixed Malignant Vs Benign
Jung Hahn 2012 [30] Asia Retrospective 110 Imaging before biopsy FLR Mixed Malignant Vs Benign
Jung Park 1 2016 [31] Asia Prospective 358 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Jung Park 2 2016 [31] Asia Prospective 358 Imaging before biopsy FLR Mixed Malignant Vs Benign
Khamis 2017 [32] Africa Prospective 120 Imaging before biopsy FLR Mixed Malignant Vs Benign
Kim Kim 2018 [33] Asia Prospective 108 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Kumm 2010 [34] North America Prospective 310 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Lee 2011 [35] Asia Retrospective 315 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Li Wang 2015 [36] Asia Retrospective 89 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Liu 2014 [37] Asia Retrospective 431 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Mansour 2012 [38] Africa Prospective 97 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Menezes 2016 [39] Asia Prospective 143 Imaging before biopsy FLR Mixed Malignant Vs Benign
Mu 2016 [40] Asia Retrospective 1080 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Mutala 2016 [41] Africa Prospective 112 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Nakashima 2018 [42] Asia Prospective 232 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Ozel 2018 [43] Europe Prospective 297 Imaging before biopsy Mixed FLR and GLR Core Biopsy Malignant Vs Benign
Ozsoy 2016 [44] Europe Prospective 168 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Parajuly 2012 [45] Asia Prospective 342 Imaging before biopsy Not Clear Mixed Malignant Vs Benign
Park 1 2020 [46] Asia Retrospective 140 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Park 2 2020 [46] Asia Retrospective 140 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Park 3 2020 [46] Asia Retrospective 140 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Rehman 2017 [47] Asia Prospective 137 Imaging before biopsy Not Clear Core Biopsy Malignant Vs Benign
Ricci 2017 [48] Europe Prospective 242 Imaging before biopsy FLR Mixed Malignant Vs Benign
Seo 2018 [49] Asia Prospective 45 Imaging before biopsy FLR Mixed Malignant Vs Benign
Singla 2019 [50] Asia Prospective 199 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Stachs 2013 [51] Europe Prospective 224 Imaging before biopsy Not Clear Not Clear Malignant Vs Benign
Stoian 2016 [52] Europe Prospective 174 Imaging before biopsy Not Clear Surgical Malignant Vs Benign
Thomas 2010 [53] Europe Prospective 227 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Turker 2017 [54] Europe Prospective 75 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Ueno 1 2015[55] Asia Prospective 98 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Ueno 2 2007 [56] Asia Not Clear 406 Imaging before biopsy Not Clear Not Clear Malignant Vs Benign
Wang 2018 [57] Asia Prospective 302 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Yagci 2017 [58] Europe Prospective 68 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Yerli 2011[59] Europe Prospective 78 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Yildiz 2020 [60] Europe Prospective 50 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Yilmaz 2017 [61] Europe Prospective 79 Imaging before biopsy FLR Core Biopsy Malignant Vs Benign
Yoon 1 2016 [62] Asia Prospective 201 Imaging before biopsy FLR Mixed Malignant Vs Benign
Yoon 2 2017 [63] Asia Prospective 243 Imaging before biopsy FLR Mixed Malignant Vs Benign
Yoon 3 2017 [63] Asia Prospective 243 Imaging before biopsy FLR Mixed Malignant Vs Benign
You 2019 [64] Asia Retrospective 373 Imaging before biopsy FLR Mixed Malignant Vs Benign
Youk 2014 [65] Asia Retrospective 79 Imaging before biopsy Not Clear Mixed Malignant Vs Benign
Zhang 1 2020 [66] Asia Prospective 91 Imaging before biopsy Mixed FLR and GLR Not Clear Malignant Vs Benign
Zhang 2 2020 [66] Asia Prospective 91 Imaging before biopsy Mixed FLR and GLR Not Clear Malignant Vs Benign
Zhao 2018 [67] Asia Retrospective 1071 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Zhi 2010 [68] Asia Prospective 559 Imaging before biopsy Mixed FLR and GLR Mixed Malignant Vs Benign
Zhou 1 2014 [69] Asia Prospective 193 Imaging before biopsy FLR Mixed Malignant Vs Benign
Zhou 2 2014 [69] Asia Prospective 193 Imaging before biopsy GLR Mixed Malignant Vs Benign
Zhou 3 2014 [70] Asia Prospective 127 Imaging before biopsy GLR Mixed Malignant Vs Benign
  1. Key
  2. 1. FLR Fat to lesion ratio
  3. 2. GLR Glandular tissue to lesion ratio
  4. 3. Mixed Any combination including core needle biopsy (CNB), FNA cytology, surgical and resolution via follow up