Table 4 Prognostic Factors for Tumor Progression* after RFA
Factor | All patients without tumor progression (N = 136, %) | All patients with tumor progression (N = 97, %) | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|---|---|
Hazard Ratio(95%CI) | P value | Hazard Ratio(95%CI) | P value | |||
Child-Pugh classification | 0.443 | |||||
 A | 127 (93.4) | 86 (88.7) | 1 (Reference) | 0.148 | 1 (Reference) | |
 B | 9 (6.6) | 11 (11.3) | 1.593 (0.847–2.993) |  | 1.290 (0.673–2.473) | |
Etiology of tumor | ||||||
 Hepatitis B virus | 102 (75.0) | 77 (79.4) | 1.395 (0.607–3.205) | 0.433 | 1.383 (0.574–3.330) | 0.470 |
 Hepatitis C virus | 11 (8.1) | 10 (10.3) | 1.888 (0.683–5.213) |  | 2.329 (0.786–6.899) | 0.127 |
 Non-B, non-C hepatitis | 8 (5.9) | 4 (4.1) | 1.372 (0.385–4.881) | 0.220 | 2.945 (0.784–11.057) | 0.110 |
 No | 15 (11.0) | 6 (6.2) | 1 (Reference) | 0.626 | 1 (Reference) | |
AFP (ng/ml) | Â | |||||
  ≤ 20 | 88 (64.7) | 52 (53.6) | 1 (Reference) |  | 1 (Reference) | |
 >20 and<400 | 37 (27.2) | 26 (26.8) | 1.387 (0.801–2.233) | 0.179 | 1.720 (1.045–2.832) | 0.033 |
  ≥ 400 | 11 (8.1) | 19 (19.6) | 3.289 (1.907–5.670) | <0.001 | 2.955 (1.652–5.283) | <0.001 |
 Tumor size (cm) | 2.40 ± 1.03 | 3.13 ± 1.13 | 1.518 (1.276–1.806) | <0.001 | 1.592 (1.313–1.930) | <0.001 |
TACE before RFA | ||||||
 Yes | 87 (64.0) | 64 (66.0) | 1.056 (0.693–1.610) | 0.800 | 0.780 (0.498–1.220) | 0.277 |
 No | 49 (36.0) | 33 (34.0) | 1 (Reference) |  | 1 (Reference) | |
Classification of HCC | ||||||
 Periportal HCC | 22 (16.2) | 63 (64.9) | 2.470 (1.622–3.761) | < | 2.417 (1.559–3.745) | < |
 Nonperiportal HCC | 114 (83.8) | 34 (35.1) | 1 (Reference) | 0.001 | 1 (Reference) | 0.001 |