Table 2 Prognostic Factors for Local Tumor Progression (LTP) after RFA
Factor | All patients without LTP (N = 189, %) | All patients with LTP (N = 40, %) | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|---|---|
Hazard Ratio(95%CI) | P value | Hazard Ratio(95%CI) | P value | |||
Child-Pugh class | 0.783 | |||||
 A | 174 (92.1) | 36 (90.0) | 1 (Reference) | 0.512 | 1(Reference) | |
 B | 15 (7.9) | 4 (10.0) | 1.416 (0.501–4.004) |  | 1.163 (0.397–3.408) | |
Etiology of tumor | ||||||
 Hepatitis B virus | 148 (78.3) | 28 (70.0) | 0.682 (0.238–1.953) | 0.476 | 0.703 (0.228–2.170) | 0.540 |
 Hepatitis C virus | 16 (8.5) | 5 (12.5) | 1.214 (0.324–4.548) |  | 1.145 (0.271–4.834) | 0.853 |
 Non-B, non-C hepatitis | 8 (4.2) | 3 (7.5) | 1.513 (0.337–6.795) | 0.774 | 3.141 (0.626–15.749) | 0.164 |
 No | 17 (9.0) | 4 (10.0) | 1 (Reference) | 0.589 | 1 (Reference) | |
AFP (ng/ml) | Â | |||||
  ≤ 20 | 115 (60.8) | 23 (57.5) | 1 (Reference) |  | 1 (Reference) | |
 >20 and<400 | 55 (29.1) | 8 (20.0) | 0.881 (0.394–1.970) | 0.757 | 1.133 (0.490–2.616) | 0.770 |
  ≥ 400 | 19 (10.1) | 9 (22.5) | 2.466 (1.090–5.576) | 0.030 | 2.431 (1.000–5.907) | 0.050 |
 Tumor size (cm) | 2.67 ± 1.13 | 3.24 ± 1.10 | 1.529 (1.172–1.994) | 0.002 | 1.553 (1.151–2.095) | 0.004 |
TACE before RFA | 0.770 | |||||
 Yes | 122 (64.6) | 28 (70.0) | 1.216 (0.616–2.401) | 0.573 | 0.898 (0.436–1.849) | |
 No | 67 (35.4) | 12 (30.0) | 1 (Reference) |  | 1 (Reference) | |
Classification of HCC | 0.024 | |||||
 Periportal HCC | 37 (19.6) | 15 (37.5) | 2.370 (1.242–4.521) | 0.009 | 2.200 (1.111–4.358) | |
 Nonperiportal HCC | 152 (80.4) | 25 (62.5) | 1 (Reference) |  | 1 (Reference) | |