Comparison of the pre-treatment functional MRI metrics’ efficacy in predicting Locoregionally advanced nasopharyngeal carcinoma response to induction chemotherapy

Table 4 Diagnostic efficacy of ADC-pre, MD-pre, MK-pre, D_slow-pre and PRE

	AUC	95%CI	Youden	Cutoff	sensitivity	specificity	+LR	-LR	+PV	-PV
ADC-pre (×10⁻⁶ mm²/s)	0.885	(0.772,0.955)	0.650	1210	75.00%	90.00%	7.50	0.28	93.1	66.7
MD-pre (×10⁻⁶ mm²/s)	0.855	(0.735,0.935)	0.556	1010	80.6%	75.0%	3.22	0.26	85.3	68.2
MK-pre (×10⁻⁶)	0.692	(0.555,0.809)	0.394	832	94.4%	45.0%	1.72	0.12	75.6	81.8
D_slow-pre (×10⁻⁶ mm²/s)	0.742	(0.608,0.850)	0.450	835	75.00%	70.00%	2.50	0.36	81.8	60.9
PRE	0.912	(0.806,0.971)	0.672	0.799	72.22%	95.00	14.44	0.29	96.3	65.5

Abbreviation: AUC: area under the curve; 95% CI: 95% confidence interval; +LR: positive likelihood ratio; −LR: negative likelihood ratio; +PV: positive predictive value; −PV: negative predictive value

ISSN: 1470-7330