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Table 3 Receiver operating characteristic curve results regarding the qualitative analysis of apparent diffusion coefficient (ADC) maps and T2weighted (T2W) images to distinguish prostate cancer from benign prostatic hyperplasia

From: Differentiating prostate cancer from benign prostatic hyperplasia using whole-lesion histogram and texture analysis of diffusion- and T2-weighted imaging

 

Parameters

AUC (95 % CI)

Sensitivity (%)

Specificity (%)

Cutoff value

p value

Youden index

+LR

-LR

ADC

5th percentile

0.906 (0.858, 0.943)

83.3

89.3

≤ 650.5

< 0.0001

0.7262

7.78

0.19

Mean

0.866 (0.811, 0.910)

73.3

92.0

≤ 858.379

< 0.0001

0.653

9.13

0.29

Median

0.861 (0.805, 0.905)

68.9

93.7

≤ 830.5

< 0.0001

0.6264

11.02

0.33

Std

0.797 (0.734, 0.850)

74.4

75.0

> 142.175

< 0.0001

0.4944

2.98

0.34

Diff-Variance

0.717 (0.649, 0.778)

78.9

61.6

> 0.18

< 0.0001

0.405

2.05

0.34

Diff-Entropy

0.717 (0.650, 0.778)

63.3

78.6

> 0.746

< 0.0001

0.419

2.96

0.47

Contrast

0.712 (0.644, 0.773)

67.8

69.6

> 0.506

< 0.0001

0.3742

2.23

0.46

Entropy

0.681 (0.612, 0.744)

70.0

64.3

> 1.668

< 0.0001

0.3429

1.96

0.47

95th percentile

0.674 (0.605, 0.738)

57.8

73.2

≤ 1135.5

< 0.0001

0.3099

2.16

0.58

Skewness

0.591 (0.520, 0.660)

65.6

54.5

> 0.299

0.0250

0.2002

1.44

0.63

Kurtosis

0.536 (0.464, 0.606)

53.3

57.1

> 0.089

0.3910

0.1048

1.24

0.82

T2W

Kurtosis

0.634 (0.563, 0.700)

48.89

79.46

> 2.082

0.0008

0.2835

2.38

0.64

Skewness

0.633 (0.562, 0.699)

60

66.96

> 0.653

0.0009

0.2696

1.82

0.6

5th percentile

0.633 (0.562, 0.699)

82.22

41.07

≤ 206.5

0.0007

0.2329

1.4

0.43

Median

0.601 (0.530, 0.669)

70

52.68

≤ 278.5

0.012

0.2268

1.48

0.57

Std

0.603 (0.532, 0.671)

53.33

68.75

> 66.431

0.0119

0.2208

1.71

0.68

Mean

0.584 (0.513, 0.653)

71.11

49.11

≤ 288.803

0.0371

0.2022

1.4

0.59

Entropy

0.511 (0.439, 0.581)

43.33

69.64

≤ 2.29

0.7993

0.1298

1.43

0.81

Diff-Variance

0.523 (0.452, 0.593)

25.56

82.14

> 0.711

0.5799

0.07698

1.43

0.91

95th percentile

0.513 (0.441,0.583)

88.89

3.57

≤ 515.5

0.7625

0.0754

0.92

3.11

Diff-Entropy

0.510 (0.439, 0.581)

42.22

65.18

> 1.526

0.8086

0.07401

1.21

0.89

Contrast

0.502 (0.431, 0.573)

32.22

74.11

≤ 1.426

0.954

0.0633

1.24

0.91

  1. AUC area under the curve, Std standard deviation, Diff-Variance difference in variance, Diff-Entropy difference in entropy
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Cancer Imaging

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