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Table 3 Receiver operating characteristic curve results regarding the qualitative analysis of apparent diffusion coefficient (ADC) maps and T2weighted (T2W) images to distinguish prostate cancer from benign prostatic hyperplasia

From: Differentiating prostate cancer from benign prostatic hyperplasia using whole-lesion histogram and texture analysis of diffusion- and T2-weighted imaging

  Parameters AUC (95 % CI) Sensitivity (%) Specificity (%) Cutoff value p value Youden index +LR -LR
ADC 5th percentile 0.906 (0.858, 0.943) 83.3 89.3 ≤ 650.5 < 0.0001 0.7262 7.78 0.19
Mean 0.866 (0.811, 0.910) 73.3 92.0 ≤ 858.379 < 0.0001 0.653 9.13 0.29
Median 0.861 (0.805, 0.905) 68.9 93.7 ≤ 830.5 < 0.0001 0.6264 11.02 0.33
Std 0.797 (0.734, 0.850) 74.4 75.0 > 142.175 < 0.0001 0.4944 2.98 0.34
Diff-Variance 0.717 (0.649, 0.778) 78.9 61.6 > 0.18 < 0.0001 0.405 2.05 0.34
Diff-Entropy 0.717 (0.650, 0.778) 63.3 78.6 > 0.746 < 0.0001 0.419 2.96 0.47
Contrast 0.712 (0.644, 0.773) 67.8 69.6 > 0.506 < 0.0001 0.3742 2.23 0.46
Entropy 0.681 (0.612, 0.744) 70.0 64.3 > 1.668 < 0.0001 0.3429 1.96 0.47
95th percentile 0.674 (0.605, 0.738) 57.8 73.2 ≤ 1135.5 < 0.0001 0.3099 2.16 0.58
Skewness 0.591 (0.520, 0.660) 65.6 54.5 > 0.299 0.0250 0.2002 1.44 0.63
Kurtosis 0.536 (0.464, 0.606) 53.3 57.1 > 0.089 0.3910 0.1048 1.24 0.82
T2W Kurtosis 0.634 (0.563, 0.700) 48.89 79.46 > 2.082 0.0008 0.2835 2.38 0.64
Skewness 0.633 (0.562, 0.699) 60 66.96 > 0.653 0.0009 0.2696 1.82 0.6
5th percentile 0.633 (0.562, 0.699) 82.22 41.07 ≤ 206.5 0.0007 0.2329 1.4 0.43
Median 0.601 (0.530, 0.669) 70 52.68 ≤ 278.5 0.012 0.2268 1.48 0.57
Std 0.603 (0.532, 0.671) 53.33 68.75 > 66.431 0.0119 0.2208 1.71 0.68
Mean 0.584 (0.513, 0.653) 71.11 49.11 ≤ 288.803 0.0371 0.2022 1.4 0.59
Entropy 0.511 (0.439, 0.581) 43.33 69.64 ≤ 2.29 0.7993 0.1298 1.43 0.81
Diff-Variance 0.523 (0.452, 0.593) 25.56 82.14 > 0.711 0.5799 0.07698 1.43 0.91
95th percentile 0.513 (0.441,0.583) 88.89 3.57 ≤ 515.5 0.7625 0.0754 0.92 3.11
Diff-Entropy 0.510 (0.439, 0.581) 42.22 65.18 > 1.526 0.8086 0.07401 1.21 0.89
Contrast 0.502 (0.431, 0.573) 32.22 74.11 ≤ 1.426 0.954 0.0633 1.24 0.91
  1. AUC area under the curve, Std standard deviation, Diff-Variance difference in variance, Diff-Entropy difference in entropy