Fig. 5
From: Integrin αvβ6-targeted MR molecular imaging of breast cancer in a xenograft mouse model
(a) Prussian blue, hematoxylin and eosin (H&E) staining of tumor tissues and liver, spleen, kidney, muscle tissues in the 4 T1 and HEK293 xenograft tumor-bearing BALB/c nude mice at 0 h, 8 h after the injection of cFK-9-USPIO or USPIO. A large number of iron blue particles were observed in the 4 T1 tumor tissues but few particles are found in HEK293 tumor tissues from mice injected with cFK-9-USPIO at 8 h. A few blue iron particles are found in liver and spleen tissues of 4 T1 and HEK293 tumor-bearing mice received cFK-9-USPIO at 8 h. For the 4 T1 tumor-bearing mice received USPIO, iron-positive cells were hardly observed in tumor tissues and a few iron blue particles are found in liver and spleen tissues at 8 h. No iron-positive cell is observed in kidney and muscle tissues in 4 T1 neither HEK293 tumor-bearing mice