Fig. 4
From: Integrin αvβ6-targeted MR molecular imaging of breast cancer in a xenograft mouse model
In vivo MRI of xenograft tumor-bearing nude mice. Axial MRI images of the 4 T1 xenograft tumor-bearing nude mice at different time points after tail-vein injection of cFK-9-USPIO (a) or USPIO (b). An evidently decreased T2 signal was observed in tumor 8 h after administration of cFK-9-USPIO probes through tail vein. In contrast, no obvious T2 signal decrease was found in 4 T1 tumor received USPIO injection. c No obvious T2 signal changes in HEK293 tumor after tail-vein injection of cFK-9-USPIO probes. d Quantitative T2 values of 4 T1 and HEK293 tumor-bearing mice after cFK-9-USPIO or USPIO injection at different time points. e Δ T2 values of 4 T1 tumors received cFK-9-USPIO probe and plain USPIO, and HEK293 tumors received cFK-9-USPIO probes injection at 1 h, 8 h, 12 h, 24 h