Exploration of spatial distribution of brain metastasis from small cell lung cancer and identification of metastatic risk level of brain regions: a multicenter, retrospective study

Table 3 Statistically significant results from the analysis based on AAL atlas

Region	Volume, mm³	Expected Rate (%)	No. Observed	Observed Rate (%)	z-Score	p-Value
hippocampus	15,024	0.79	7	0.68	−0.39	0.699
parahippocampus	16,880	0.89	10	0.97	0.30	0.763
brainstem	40,087	2.11	21	2.05	−0.13	0.896
caudatum	15,648	0.82	7	0.68	−0.49	0.621
putamen	16,584	0.87	7	0.68	−0.65	0.516
pallidum	4584	0.24	2	0.2	−0.30	0.765
pituitary gland	1088	0.06	0	0	−0.785	0.444
pineal gland	404	0.02	0	0	−0.467	0.641
amygdala	3744	0.19	0	0	−1.422	0.155
precentral gyrus	55,256	2.9	46	4.48	3.02	0.003
inferior frontal gyrus	84,112	4.42	23	2.24	−3.39	6.971 ×10⁻⁴
cingulate gyrus	61,240	3.22	31	3.03	−0.35	0.724
occipital gyrus (superior, middle, inferior)	80,616	4.23	31	3.0	−1.93	0.054
supramarginal gyrus	25,840	1.36	5	0.49	−2.41	0.016
temporal pole	36,520	1.92	12	1.17	−1.75	0.081
Heschl’s gyrus	3792	0.19	3	0.29	0.67	0.503
gyrus temporalis superior	43,496	2.28	10	0.97	−2.81	0.005
gyrus temporalis medius	74,808	3.93	29	2.82	−1.82	0.069
gyrus temporalis inferior	54,056	2.83	21	2.05	−1.53	0.127
cerebellar hemispheres	104,904	5.51	101	9.84	6.09	1.177 ×10⁻⁹
vermis cerebelli	16,320	0.86	10	0.98	0.41	0.683
cerebellar peduncle	74,096	3.89	60	5.85	3.24	0.001

ISSN: 1470-7330