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Table 3 Overview of radiopharmaceuticals

From: The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review

Tracer Intended usea
18F-fluorodeoxyglucose (18F-FDG) Visualization of increased glucose metabolism / inflammatory activity [36]
18F-3′-fluoro-3′-deoxy-L-thymidine (18F-FLT) Visualization of DNA-synthesis / cellular proliferation [37]
Labeled colloids
99mTc, 198Au, 113mIn
Visualization of reticuloendothelial system / medullary stroma [25, 39]
111In-Chloride (111In-Cl3) Visualization of erythropoietic activity [39]
Labeled iron
59Fe, 52Fe
Visualization of erythropoietic marrow [40, 45]
Labeled red blood cells (RBC’s)
99mTc or 113mIn
Visualization of RBC pools; heat-damaged RBC’s for assessment of spleen volume [71]
99mTc-leukocytes Visualization of hematopoiesis [41] (standard use for detection of inflammation)
99mTc-antigranulocyte antibodies
(99mTc-AGAb)
Visualization of granulocyte (precursors) / granulopoeisis [46]
99mTc-low density lipoprotein (99mTc-LDL) Visualization of LDL biodistribution / catabolism [47]
99mTc-methylene-diphosphonate
(99mTc-MDP)
Visualization of bone matrix turnover and/or blood flow [42]
133Xe Evaluation of blood flow [60] (standard use for ventilation studies)
15O-carbon dioxide (15O-CO2) Evaluation of blood flow [61]
  1. a Concerns the intended use of the tracer as reported by the articles under review. A random choice of relevant references were appended for background reading
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