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Table 3 Overview of radiopharmaceuticals

From: The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review

Tracer

Intended usea

18F-fluorodeoxyglucose (18F-FDG)

Visualization of increased glucose metabolism / inflammatory activity [36]

18F-3′-fluoro-3′-deoxy-L-thymidine (18F-FLT)

Visualization of DNA-synthesis / cellular proliferation [37]

Labeled colloids

99mTc, 198Au, 113mIn

Visualization of reticuloendothelial system / medullary stroma [25, 39]

111In-Chloride (111In-Cl3)

Visualization of erythropoietic activity [39]

Labeled iron

59Fe, 52Fe

Visualization of erythropoietic marrow [40, 45]

Labeled red blood cells (RBC’s)

99mTc or 113mIn

Visualization of RBC pools; heat-damaged RBC’s for assessment of spleen volume [71]

99mTc-leukocytes

Visualization of hematopoiesis [41] (standard use for detection of inflammation)

99mTc-antigranulocyte antibodies

(99mTc-AGAb)

Visualization of granulocyte (precursors) / granulopoeisis [46]

99mTc-low density lipoprotein (99mTc-LDL)

Visualization of LDL biodistribution / catabolism [47]

99mTc-methylene-diphosphonate

(99mTc-MDP)

Visualization of bone matrix turnover and/or blood flow [42]

133Xe

Evaluation of blood flow [60] (standard use for ventilation studies)

15O-carbon dioxide (15O-CO2)

Evaluation of blood flow [61]

  1. a Concerns the intended use of the tracer as reported by the articles under review. A random choice of relevant references were appended for background reading