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Table 2 Imaging Features of Fumarate Hydratase-Deficient Renal Cell Carcinoma

From: Imaging features of fumarate hydratase-deficient renal cell carcinomas: a retrospective study

Imaging Features n (%)
Tumor Location and Size
 Left 8 (50)
 Right 7 (44)
 Bilateral 1 (6)
 Size mean centimeters (range) 10.3 (2.2–18)
 Size median centimeters 9.8
General Tumor Features
 Unifocal 15 (94)
 Multifocal bilateral 1 (6)
 Infiltrative margin 14 (88)
 Circumscribed margin 2 (12)
 Large cystic or necrotic component 8 (50)
 Involvement of renal sinus fat 13 (81)
 Involvement of hilar collecting system 8 (50)
 Heterogenous enhancement 16 (100)
 Peritumoral vascularity 9 (56)
 Renal vein thrombus 6 (38)
 Retroperitoneal nodal metastases 11 (69)
 Distant metastases at presentation 12 (75)
 No metastases at presentation 4 (25)
CT-Specific Tumor Features
 Calcifications 0
MRI-Specific Tumor Features
 T1 hemorrhage 7 (58)
 Intravoxel fat 0
 T2 signal heterogeneity 12 (100)
 Diffusion restriction in solid component 11 (100)
PET-Specific Tumor Features
 FDG avidity above liver background 3 (100)
 SUVmax mean (range) 16.4 (9.6–21.9)
  1. CT computed tomography, MRI magnetic resonance imaging, DWI diffusion-weighted imaging, FDG PET fluorodeoxyglucose positron emission tomography, SUVmax maximum standardized uptake value
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