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Table 1 Parameters of MR imaging

From: Assessment of tissue perfusion of pancreatic cancer as potential imaging biomarker by means of Intravoxel incoherent motion MRI and CT perfusion: correlation with histological microvessel density as ground truth

Sequence type

Breathing position

Coverage

Orientation

TR [ms]

TE [ms]

Acquisition matrix

Slice thickness/ gap [mm]

Pixel bandwidth [Hz]

 

1) Anatomic MR imaging (performed in every patient)

T1-weighted in/opposed phase

Inspiratory breath-hold

Upper abdomen

Transverse

115

2.27 and 4.78

320 × 272

5 / 1

445

 

HASTE-IR T2-weighted

Inspiratory breath-hold

Upper abdomen

Coronal

1000

80

256 × 230

6 / 0.6

545

 

HASTE T2-weighted

Expiratory breath-hold

Upper abdomen

Transverse

680

95

320 × 320

4 / 0.4

505

 

2) Diffusion weighted MR imaging (performed in every patient)

ss-EPI

Expiratory breath-hold

Pancreas

Transverse

2200

58

130 × 92

5 / 0.25

2260

Pixel spacing: 2.7 mm/ 2.7 mm;

Number of acquired slices per b-value: 14;

b-values [s/mm2]: 0, 50, 100, 150, 200, 300, 400, 600, and 800;

Number of excitations: 1 for b = 0 s/mm2, 2 for every other b-value;

Number of diffusion-encoding gradient directions: 3;

K-space based parallel imaging technique (GRAPPA); acceleration factor: 2;

Fat saturation technique: spectral fat saturation.

The acquisition was separated into blocks (b0, b50), (b0, b100) … (b0, b800). Each block was acquired in a single breath-hold in expiration (TA = 22 s) to avoid motion artifacts. No registration for correction of patient breathing-motion was applied.

  1. The pancreatic MR imaging protocol consisted of 1) anatomic imaging sequences, and 2) diffusion weighted imaging with 9 b-values. An experienced radiologist directly involved in the study was always present during MR imaging. Abbreviations: n.a.: not applicable, fs: fat saturation, HASTE: Half-Fourier-Acquired Single-shot Turbo spin Echo, ss-EPI: Single-shot Echo-Planar Imaging, TE: echo time, TR: repetition time