Fig. 3
Image examples of a patient with comparatively high tumor vascularity. 58 years old male patient with PDAC of the pancreatic head. a-c Axial MR images with the patient in supine position. a Axial T2-HASTE MR image shows upstream dilatation of the main pancreatic duct (green arrow) due to an obstructing tumor in the pancreatic head (red arrow). Stent in the distal common bile duct which is not dilated (pink arrowhead). b Diffusion-weighted MR image (b = 300 s/mm2) caudad to the T2-HASTE image with a VOI encompassing the tumor (VOI tumor). c Diffusion-weighted MR imaging with overlaying color-coded f-map. Mean calculated ftumor-value for both readers was high (22.1%). d–f Axial CT images with the patient in an oblique, 30°, right-sided down position. D) Temporal maximum intensity projection (MIP) CT images of the perfusion sequence with VOIs encompassing the pancreas (VOI pancreas) and the tumor (VOI tumor). e–f Temporal MIP CT images with color-coded parameter maps for blood flow (BFtumor, e) and blood volume (BVtumor, f) derived from perfusion-sequence. Mean BFtumor and BVtumor were comparatively high (77.3 ml/100 ml/min and 8.2 ml/100 ml). g Representative cutout of corresponding immunostained tissue slide (CD34) after semi-automated segmentation of microvessels shows high MVDtumor. MVDtumor in total analysis area was 61.8/mm2