Fig. 1
Example of measurement of tumor ADC by manual placement of regions of interest A patient with a history of lung adenocarcinoma presents with headache and focal neurological deficit. a. T1 weighted MRI with gadolinium demonstrates a left parietal lesion, which was confirmed as a metastasis by pathology. b. ADC map is generated from DWI using post processing software and fused to the T1 post contrast study. C and D are zoomed images of B as outlined in green. c. A region of interest is traced around the tumor border using the T1-weighted post gadolinium scan and then applied to the ADC map. d. Regions of interest of an agreed size - here five circles of 50mm2 -are placed within the tumor on the axial slice with the largest area, avoiding necrosis, haemorrhage or cyst, and the overall mean is calculated