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Table 4 Diagnostic accuracy of PET/MRI and MRI for the detection of local tumor invasion and lymph node metastasis on a regional level

From: Diagnostic efficiency of whole-body 18F-FDG PET/MRI, MRI alone, and SUV and ADC values in staging of primary uterine cervical cancer

Regions

PET/MRI

MRI

Sens

Spec

Acc

PPV

NPV

AUC (95% CI)

Sens

Spec

Acc

PPV

NPV

AUC (95% CI)

Local invasion

 Deep stromal a (positive 9/20)

100%

91%

95%

90%

100%

0.96 (0.85–1.00)

89%

60%

74%

67%

86%

0.74 (0.51–0.98)

 Vaginal (positive 12/33)

75%

95%

88%

90%

87%

0.85 (0.69–1.00)

100%

48%

67%

52%

100%

0.74 (0.57–0.91)

 Parametrial (positive 10/33)

90%

87%

88%

75%

95%

0.89 (0.75–1.00)

100%

46%

63%

46%

100%

0.73 (0.56–0.90)

Lymph node metastasis

 Pelvic right (LNM in 12/33)

67%

91%

82%

80%

83%

0.79 (0.61–0.97)

75%

71%

73%

60%

83%

0.73 (0.55–0.92)

 Pelvic left (LNM in 12/33)

42%

91%

73%

71%

73%

0.66 (0.46–0.87)

58%

91%

79%

78%

79%

0.74 (0.55–0.94)

 Para-aortic (LNM in 4/33)

50%

100%

94%

100%

94%

0.75 (0.43–1.00)

50%

96%

91%

67%

93%

0.73 (0.41–1.00)

  1. Sens sensitivity, Spec specificity, Acc accuracy, PPV positive predictive value, NPV negative predictive value, AUC area under the curve, CI confidence interval, LNM lymph node metastasis
  2. a ≥ 50% of the cervical stroma thickness; evaluated only in patients with histological reference