Table 3 Receiver Operating Characteristic Curve Analysis of DECT Quantitative Parameters for the DifferentialDiagnosis of Immunohistochemical Factors in Invasive Breast Cancer
Parameter | AUC | Threshold of Parameter | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|
ER positive vs. negative | |||||
 Venous phase NIC | 0.65 [0.56, 0.75] | 0.293 | 88.4 (76/86) [79.2, 94.0] | 41.2 (14/34) [25.1, 59.2] | 75.0 (90/120) [66.5, 81.9] |
 Venous phase nZeff | 0.60 [0.49, 0.70] | 0.87 | 70.9 (61/86) [60.0, 80.0] | 50.0 (17/34) [32.8, 67.2] | 65.0 (78/120) [56.1, 73.0] |
PR positive vs. negative | |||||
 Arterial phase NIC | 0.63 [0.53, 0.73] | 0.082 | 75.5 (40/53) [61.4, 85.9] | 50.7 (34/67) [38.4, 61.0] | 61.7 (74/120) [52.7, 69.9] |
 Venous phase NIC | 0.65 [0.55, 0.75] | 0.356 | 62.3 (33/53) [47.9, 74.9] | 62.7 (42/67) [50.0, 73.1] | 62.5 (75/161) [53.6, 70.7] |
HER2 positive vs. negative | |||||
 Venous phase nZeff | 0.59 [0.49, 0.69] | 0.87 | 70.2 (33/47) [54.9, 82.2] | 53.4 (39/73) [41.4, 65.0] | 60.0 (72/120) [51.1, 68.3] |
Ki67 low- vs. high-proliferation | |||||
 Arterial phase NIC | 0.67 [0.57, 0.77] | 0.079 | 80.0 (56/70) [68.4, 88.3] | 54.0 (27/50) [39.5, 67.9] | 69.2 (83/120) [60.4, 76.8] |
 Venous phase NIC | 0.75 [0.67, 0.84] | 0.281 | 88.6 (62/70) [78.2, 94.6] | 52.0 (26/50) [37.6, 66.1] | 73.3 (88/120) [64.8, 80.5] |
 Arterial phase nZeff | 0.70 [0.60, 0.79] | 0.73 | 65.7 (46/70) [53.3, 76.4] | 62.0 (31/50) [47.2, 75.0] | 64.2 (77/120) [55.3, 72.2] |
 Venous phase nZeff | 0.67 [0.57, 0.77] | 0.86 | 74.3 (52/70) [62.2, 83.7] | 50.0 (25/50) [35.7, 64.3] | 64.2 (77/120) [55.3, 72.2] |